PUBLICATIONS

Our students have published their research in a wide variety of high-impact scientific journals. Please see below a list of all SBM CDT research publications.

Preprints
P4. Reverse Polarity Reductive Functionalization of Tertiary Amides via a Dual Iridium Catalyzed Hydrosilylation & SET Strategy.
Rogova, T., Gabriel, P., Zavitsanou, S., Leitch, J. A., Duarte, F. and Dixon, D. J.
ChemRxiv, 2020, Preprint.
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P3. α-Tertiary Dialkyl Ether Synthesis via Reductive Photocatalytic α-Functionalization of Alkyl Enol Ethers.
Leitch, J. A., Rossolini, T., Rogova, T. and Dixon, D. J.
ChemRxiv, 2020, Preprint.
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P2. Controlling Intramolecular Interactions in the Design of Selective, High-Affinity, Ligands for the CREBBP Bromodomain.
Brand, M., Clayton, J., Moroglu, M., Schiedel, M., Picaud, S., Bluck, J., Skwarska, A., Chan, A., Laurin, C., Scorah, A., See, L., Rooney, T., Fedorov, O., Perell, G., Kalra, P., Cortopassi, W., Christensen, K., Cooper, R., Patom, R., Pomerantz, W., Biggin, P., Hammond, E. M., Filippakopoulos, P. and Conway, S. J.
ChemRxiv, 2020, Preprint.
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P1. Mechanistic Investigation of Rh(I)-Catalyzed Asymmetric Suzuki-Miyaura Coupling with Racemic Allyl Halides
van Dijk, L., Ardkhean, R., Sidera, M., Karabiyikoglu, S., Sari, O., Claridge, T. D. W., Paton, R. S. and Fletcher, S. P.
ChemRxiv, 2019, Preprint.

2020
126. A Modular and Divergent Approach to Spirocyclic Pyrrolidines.
Shennan, B., Smith, P., Ogura, Y. and Dixon, D. J.
Chem. Sci., 2020, Accepted Manuscript.
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125. Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C–O Cross-Coupling.
Szpera, R., Isenegger, P. G., Ghosez, M., Straathof, N., Cookson, R., Blakemore, D., Richardson, P. and Gouverneur, V.
Org. Lett., 2020, Article ASAP.
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124. Catalytic Reductive Functionalization of Tertiary Amides using Vaska’s Complex: Synthesis of Complex Tertiary Amine Building Blocks and Natural Products..
Matheau-Raven, D., Gabriel, P., Leitch, J. A., Almehmadi, Y. A., Yamazaki, K. and Dixon, D. J.
ACS Catal., 2020, 10, 8880.
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123. Coupled metabolic cycles allow out‐of‐equilibrium autopoietic vesicle replication.
Engwerda, A., Southworth, J., Lebedeva, M., Scanes, R., Kukura, P. and Fletcher, S. P.
Angew. Chem. Int. Ed., 2020, Accepted Article.
122. Selective fragments for the CREBBP bromodomain identified from an Encoded Self‑Assembly Chemical Library.
Catalano, M., Moroglu, M., Balbi, P., Mazzieri, F., Clayton, J., Andrews, K. H., Bigatti, M., Scheuermann, J., Conway, S. J. and Neri, D.
ChemMedChem, 2020, Accepted Article.
121. A Heck reaction/photochemical alkene isomerization sequence to prepare functionalized quinolines.
Kelly, A., Hoffman, J. B., Hoff, O., Walker, J., Werrel, S. and Donohoe, T. J.
Tetrahedron, 2020, In Press.
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120. Controlling gene expression with light: a multidisciplinary endeavour.
Hartmann, D., Smith, J., Mazzotti, G., Chowdhry, R. and Booth, M. J.
Biochem Soc Trans, 2020, Accepted Article.
119. Synthesis of Cyclo[18]carbon via Debromination of C18Br6.
Scriven, L. M., Kaiser, K., Schulz, F., Sterling, A. J., Woltering, S. L., Gawel, P., Christensen, K. E., Anderson, H. L. and Gross, L.
J. Am. Chem. Soc., 2020, 142, 12921.
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118. Atropisomerism in diarylamines: structural requirements and mechanisms of conformational interconversion.
Costil, R., Sterling, A. J., Duarte, F. and Clayden, J.
Angew. Chem. Int. Ed., 2020, Accepted Article.
117. Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of γ-Fluoroamines.
Ascough, D. M. H., Roagna, G., Ibba, F., Vicini, A., Fontana, A., Christensen, K. E., Peschiulli, A., Oehlrich, D., Misale, A., Trabanco, A. A., Paton, R. S., Pupo, G. and Gouverneur V.
J. Am. Chem. Soc., 2020, Article ASAP.
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116. Single‐molecule observation of intermediates in bioorthogonal 2‐cyanobenzothiazole chemistry.
Qing, Y., Liu, M..D., Hartmann, D., Zhou, L., Ramsay, W..J. and Bayley, H.
Angew. Chem. Int. Ed., 2020, Accepted Article.
115. BIMP Catalyzed 1,3-Prototropic Shift for the Highly Enantioselective Synthesis of Conjugated Cyclohexenones.
Golec, J., Carter, E., Ward, J., Whittingham, W., Simon, L., Paton, R. and Dixon, D. J.
ChemRxiv, 2020, Preprint.
Angew. Chem. Int. Ed.,
2020, Early View.
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114. Structure-activity relationship study of cytotoxic neolignan derivatives using multivariate analysis and computation-aided drug design.
de Sousa, F. S., Baldim, J. L., Azevedo, R. A., Figueiredo, C. R., Pieper, P., Sear, C. E., Anderson, E. A. and Lago, J. H. G.
Bioorg. Med. Chem. Lett., 2020, 30, 127349.
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113. Reversible photo-control over transmembrane anion transport using visible-light responsive supramolecular carriers.
Kerckhoffs, A. and Langton, M. J.
ChemRxiv, 2020, Preprint.
Chem. Sci.,
2020, 11, 6325.
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112. Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction.
Darlot, B., Eaton, J. R. O., Geis-Asteggiante, L., Yakala, G. K., Karuppanan, K., Davies, G., Robinson, C. V., Kawamura, A. and Bhattacharya, S.
J. Biol. Chem., 2020, Accepted Article.
110. Organophotochemical SNAr Reactions of Mildly Electron‐Poor Fluoroarenes.
Sheridan, T., Yayla, H., Lian, Y., Genovino, J., Monck, N. and Burton, J. W.
Eur. J. Org. Chem., 2020, 2766.
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109. Synthesis of All-carbon Disubstituted Bicyclo[1.1.1]pentanes by Iron-Catalyzed Kumada Cross-Coupling.
Nugent, J., Shire, B., Caputo, D. F. J., Pickford, H. D., Nightingale, F., Houlsby, I. T. T., Mousseau, J. J. and Anderson, E. A.
Angew. Chem. Int. Ed., 2020, 59, 11866.
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108. Control of Absolute Stereochemistry in Transition‐Metal‐Catalyzed Hydrogen Borrowing Reactions.
Kwok, T., Hoff, O., Armstrong, R. J. and Donohoe, T. J.
Chem. Eur. J., 2020, Accepted Article.
107. Consecutive 5′- and 3′-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response.
Epple, S., Thorpe, C., Baker, Y. R., El-Sagheer, A. H. and Brown, T.
Chem. Commun., 2020, 56, 5496.
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106. Transmembrane anion transport mediated by halogen bonding and hydrogen bonding triazole anionophores.
Bickerton, L. E. E., Sterling, A.J., Beer, P. D., Duarte, F. and Langton, M. J.
Chem. Sci., 2020, 11, 4722.
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105. Rationalizing the diverse reactivity of [1.1.1]propellane through sigma-pi-delocalization.
Sterling, A. J., Durr, A.B., Smith, R.C., Anderson, E.A. and Duarte, F.
ChemRxiv, 2019, Preprint.
Chem. Sci.,
2020, 11, 4895.
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104. Enantiomerically Enriched Tetrahydropyridine Allyl Chlorides.
Karabiyikoglu, S., Brethomé, A., Palacin, T., Paton, R., and Fletcher, S. P.
ChemRxiv, 2019, Preprint.
Chem. Sci.,
2020, 11, 4125.
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103. An Asymmetric Suzuki–Miyaura Approach to Prostaglandins: Synthesis of Tafluprost.
Kucera, R., Goetzke, F. W. and Fletcher, S. P.
Org. Lett. 2020, 22, 2991.
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102. A hydrogen borrowing annulation strategy for the stereocontrolled synthesis of saturated aza-heterocycles.
Chamberlain, A. E. R., Paterson, K. J., Armstrong, R. J., Twin, H. C. and Donohoe, T. J.
Chem. Commun., 2020, 56, 3563.
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101. Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis.
Cheang, D. M. J., Armstrong, R. J., Akhtar, W. M. and Donohoe, T. J.
Chem. Commun., 2020, 56, 3543.
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100. Double and triple ionization of isocyanic acid.
Eland, J.H.D., Squibb, R.J., Sterling, A.J., Wallner, M., Hult Roos, A., Andersson, J., Axelsson, V., Johansson, E., Teichter, A., Stranges, S., Brunetti, B., Dyke, J.M., Duarte, F. and Feifel, R.
arRxiv, 2019, Preprint.
Sci. Rep.,
2020, 10, 2288.
99. Mechanistic Studies of the Palladium-Catalyzed Desulfinative Cross-Coupling of Aryl Bromides and (Hetero)Aryl Sulfinate Salts.
Gombert, A., McKay, A. I., Davis, C. J., Wheelhouse, K. M. and Willis M. C.
J. Am. Chem. Soc., 2020, 142, 3564.
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98. A Modular, Enantioselective Synthesis of Resolvins D3, E1, and Hybrids.
Urbitsch, F., Elbert, B. L., Llaveria, J., Streatfeild, P. E. and Anderson, E. A.
Org. Lett., 2020, 22, 1510.
Stacks Image 9448
97. Synthesis of the cyclopentane core of pepluanin A.
Shepherd, E. D., Hallside, M. S., Sutro, J. L., Thompson, S., Hutchings, M. and Burton, J. W.
Tetrahedron, 2020, 76, 130981.
Stacks Image 9454
96. Chemo- and Regioselective Synthesis of Acyl-Cyclohexenes by a Tandem Acceptorless Dehydrogenation-[1,5]-Hydride Shift Cascade.
Smith, L. B., Armstrong, R. J., Matheau-Raven, D. and Donohoe, T. J.
J. Am. Chem. Soc., 2020, 142, 2514.
Stacks Image 9431
95. α-Amino Radicals via Photocatalytic Single-Electron Reduction of Imine Derivatives.
Leitch, J. A., Rossolini, T., Rogova, T., Maitland, J. A. P. and Dixon, D. J.
ACS Catal., 2020, 10, 2009.
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94. Bicyclic Lactams Derived from Serine or Cysteine and 2-Methylpropanal.
Bagum, H., Shire, B. R., Christensen, K. E., Genov, M., Pretsch, S., Pretsch, D. and Moloney, M. G.
Synlett, 2020, 31, 378.
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93. 18F-Trifluoromethanesulfinate Enables Direct C–H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides.
Kee, C. W., Tack, O., Guibbal, F., Wilson, T. C., Isenegger, P. G., Imiołek, M., Verhoog, S., Tilby, M., Boscutti, G., Ashworth, S., Chupin, J., Kashani, R., Poh, A. W. J., Sosabowski, J. K., Macholl, S., Plisson, C., Cornelissen, B., Willis, M. C., Passchier, J., Davis, B. G. and Gouverneur, V.
J. Am. Chem. Soc., 2020, 142, 1180.
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92. Dearomative Photocatalytic Construction of Bridged 1,3-Diazepanes.
Leitch, J., Rogova, T., Duarte, F. and Dixon, D. J.
ChemRxiv, 2019, Preprint.
Angew. Chem. Int. Ed.,
2020, 59, 4121.
Stacks Image 9407

2019
91. Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.
Ni, X., Heidenreich, D., Christott, T., Bennett, J., Moustakim, M., Brennan, P.E., Fedorov, O., Knapp, S. and Chaikuad, A. 
ACS Med. Chem. Lett., 2019, 10, 1661.
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90. Iridium-Catalyzed Reductive Coupling of Grignard Reagents and Tertiary Amides.
Gabriel, P., Xie, L-G. and Dixon, D. J.
Org. Synth., 2019, 96, 511.
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89. Synthesis of highly fluorinated arene complexes of [Rh(chelating phosphine)]+ cations, and their use in synthesis and catalysis.
McKay, A., Barwick–Silk, J., Savage, M., Willis, M. C. and Weller, A. S.
Chem. Eur. J., 2020, 26, 2883.
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88. 19F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode.
Leśniak, R. K., Rydzik, A. M., Kamps, J.J.A.G., Kahn, A., Hopkinson, R.J., Schofield, C.J. and Claridge, T. D. W.
Chem. Commun., 2019, 55, 14717.
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87. How formaldehyde reacts with amino acids.
Kamps, J.J.A.G., Hopkinson, R.J., Schofield, C.J. and Claridge, T. D. W.
Commun Chem, 2019, 2, 126.
86. Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase.
Wilkinson, I. V. L., Reynolds, J. K., Galan, S. R. G., Vuorinen, A., Sills, A. J., Pires, E., Wynne, G. M., Wilson, F. X., Russell, A. J.
Bioorg. Chem., 2020, 94, 103395.
85. Synthesis of Cyclic Alkenyl Dimethylsiloxanes from Alkynyl Benzyldimethylsilanes and Application in Polyene Synthesis
Gudmundsson, H. G., Kuper, C. J., Cornut, D., Urbitsch, F., Elbert, B. and Anderson, E. A.
J. Org. Chem., 2019, 84, 14868.
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84. Convergent Total Syntheses of (−)‐Rubriflordilactone B and (−)‐pseudo‐Rubriflordilactone B
Mohammad, M., Chintalapudi, V., Carney, J. M., Mansfield, S. J., Sanderson, P., Christensen, K. E. and Anderson, E. A.
Angew. Chem. Int. Ed., 2019, 58, 18177.
Stacks Image 9351
83. Highly enantioselective rhodium-catalyzed cross-coupling of boronic acids and racemic allyl halides.
González, J., van Dijk, L., Goetzke, F.W. and Fletcher, S.P.
Nature Protocols, 2019, 14, 2972.
82. A General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis
Nugent, J., Arroniz, C., Shire, B. R., Sterling, A. J., Pickford, H. D., Wong, M. L. J., Mansfield, S. J., Caputo, D. F. J., Owen, B., Mousseau, J. J., Duarte, F. and Anderson, E. A.
ChemRxiv, 2019, Preprint.
ACS Catal.,
2019, 9, 9568.
Stacks Image 9229
81. Desymmetrization of Meso-bisphosphates via Rhodium Catalyzed Asymmetric Allylic Arylation
Jacques, R., Hell, A., Pullin, R. and Fletcher, S.
Tetrahedron, 2019, 75, 130560.
Stacks Image 9327
80. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
Krajnc, A., Brem, J., Hinchliffe, P., Calvopiña, K., Panduwawala, T.D., Lang, P.A., Kamps, J.J.A.G., Tyrrell, J.M, Widlake, E., Saward, B.G., Walsh, T.R, Spencer, J., and Schofield, C.J.
J. Med. Chem. 2019, 62, 8544.
Stacks Image 9339
79. Modular Sulfondiimine Synthesis Using a Stable Sulfinylamine Reagent
Zhang, Z.-X., Davies, T. Q., Willis, M. C.
J. Am. Chem. Soc., 2019, 141, 13022.
Stacks Image 9321
78. Iridium-Catalyzed Aza-Spirocyclization of Indole-Tethered Amides: An Interrupted Pictet–Spengler Reaction
Gabriel, P., Gregory, A. W., Dixon, D. J.
Org. Lett., 2019, 21, 6658.
Stacks Image 9310
77. Retooling Asymmetric Conjugate Additions for Sterically Demanding Substrates with an Iterative Data-Driven Approach
Brethome, A. V., Paton, R. S. and Fletcher, S. P.
ChemRxiv, 2019, Preprint.
ACS Catal.,
2019, 9, 7179.
Stacks Image 9301
75. Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications
Thorpe, C., Epple, S., Woods, B., El-Sagheer, A. H. and Brown, T.
Org. Biomol. Chem., 2019, 17, 5341.
Stacks Image 9281
74. Intramolecular Aldol Ring Closures of Cysteine Derivatives Leading to Densely Functionalised Pyroglutamates
Almahli, H., Jimenez, N. C. and Moloney, M. G.
Synlett, 2019, 30, 1237.
Stacks Image 9275
73. Total Synthesis of Berkeleylactone A
Ferko, B., Zeman, M., Formica, M., Veselý, S., Doháňošová, J., Moncol, J., Olejníková, P., Berkes, D., Jakubec, P., Dixon, D. J. and Caletkova, O.
J. Org. Chem., 2019, 84, 7159.
Stacks Image 9261
72. Dehydrodieugenol B derivatives as antiparasitic agents: Synthesis and biological activity against Trypanosoma cruzi
Ferreira, D. D., Sousa, F. S., Costa-Silva, T. A., Reimão, J. Q., Torrecilhas, A. C., Johns, D. M., Sear, C. E., Honorio, K. H., Lago, J. H. G., Anderson, E. A. and Tempone, A. G.
Eur. J. Med. Chem., 2019, 176, 162.
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71. A General Copper-Catalyzed Synthesis of Ynamides from 1,2-Dichloroenamides​
Mansfield, S. J., Smith, R. C., Yong, J. R. J., Garry, O. L. and Anderson, E. A.
Org. Lett., 2019, 21, 2918.
Stacks Image 9209
70. A halogen-bonding foldamer molecular film for selective reagentless anion sensing in water
Hein, R., Borissov, A., Smith, M. D., Beer, P. D. and Davis, J. J
Chem. Commun., 2019, 55, 4849.
Stacks Image 9235
69. Synthesis of Enantioenriched α‐Chiral Bicyclo[1.1.1]pentane​​
Wong, M. L. J., Mousseau, J. J., Mansfield, S. J. and Anderson, E. A.
Org. Lett., 2019, 21, 2408.
Stacks Image 9223
68. A chemically fuelled self-replicator
Morrow, S. M., Colomer, I. and Fletcher, S. P.
Nat. Commun., 2019, 10, 1011.
Stacks Image 9200
67. Practical and scalable kinetic resolution of BINOLs mediated by a chiral counterion
Jones, B. A., Balan, T., Jolliffe, J. D., Campbell, C. D., Smith, M. D.
Angew. Chem. Int. Ed., 2019, 58, 4596.
Stacks Image 9183
66. Dithiane-Directed Rh(III)-Catalyzed Amidation of Unactivated C(sp3)-H Bonds
Shi, H. and Dixon, D. J.
Chem. Sci., 2019, 10, 3733.
Stacks Image 9194
65. The fluorination of C–H bonds: developments and perspectives​
Szpera, R., Moseley, D. F. J., S., Smith, L. B., Sterling, A. J., Gouverneur, V.
Angew. Chem. Int. Ed., 2019, 58, 14824.
Stacks Image 9296
64. Primary α-Tertiary Amine Synthesis via α-C–H Functionalization
Vasu, D., Fuentes de Arriba, A. L., Leitch, J. A., de Gombert, A. and Dixon, D. J.
ChemRxiv, 2018, Preprint.
Chem. Sci.,
2019, 10, 3401.
Stacks Image 9192
63. Anion recognition in water by charge-neutral halogen and chalcogen bonding foldamer receptors​
Borissov, A., Marques, I., Lim, J. Y. C., Félix, V., Smith, M. D. and Beer, P. D.
J. Am. Chem. Soc., 2019, 141, 4119.
Stacks Image 9164
62. Chemical Probes​
Donner, A., King, H., Brennan, P. E., Moustakim, M. and Zuercher, W. J.
in Epigenetic Drug Discovery, 2019, 133.
61. Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines
Pupo, G., Vicini, A. C., Ascough, D. M. H., Ibba, F., Christensen, K. E., Thompson, A. L., Brown, J. M., Paton, R. S. and Gouverneur, V.
J. Am. Chem. Soc., 2019, 141, 2878.
Stacks Image 9171
60. Conformational Effects on Physical-Organic Descriptors – the Case of Sterimol Steric Parameters​
Brethome, A., Fletcher, S. P., Paton, R. S.
ChemRxiv, 2018, Preprint.
ACS Catal.,
2019, 9, 2313.
Stacks Image 9174
59. Hydrogen bond enabled dynamic kinetic resolution of axially chiral amides mediated by a chiral counterion
Fugard, A. J., Lahdenperä, A. S. K., Tan, J. S. J., Mekareeya, A., Paton, R. S., Smith, M. D.
Angew. Chem. Int. Ed., 2019, 58, 2795.
Stacks Image 9143
58. Chemical epigenetics: the impact of chemical‐ and chemical biology techniques on bromodomain target validation​
Schiedel, M., Moroglu, M., Ascough, D. M. H., Chamberlain, A. E. R., Kamps, J. J. A. G., Sekirnik, A. R., Conway, S. J.
Angew. Chem. Int. Ed., 2019, 58, 17930.
Stacks Image 9366
57. Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
Jacques, R., Pullin, R. D. C. and Fletcher, S. P.
ChemRxiv, 2018, Preprint.
Nat. Commun.,
2019, 10, 21.
Stacks Image 9149
56. Data-mining the diaryl(thio)urea conformational landscape: Understanding the contrasting behavior of ureas and thioureas with quantum chemistry
Luchini, G., Ascough, D.M.H., Alegre-Requena, J. V., Gouverneur, V. and Paton, R. S.
Tetrahedron, 2019, 75, 697.
Stacks Image 9202
55. Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by L,D‐Transpeptidases and Serine β‐Lactamase Cysteine Variants
Chan, H. T. H., Lohans, C. T., Malla, T. R., Kumar, K., Kamps, J. J. A. G., McArdle, D. J. B., van Groesen, E., de Munnik, M., Tooke, C. L., Spencer, J., Paton, R. S., Brem, J. and Schofield, C. J.
Angew. Chem. Int. Ed., 2019, 58, 1990.
Stacks Image 9162
54. Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides
Hyde, S., Veliksa, J., Ascough, D. M. H., Szpera, R., Paton, R. S., Gouverneur, V.
Tetrahedron, 2019, 75, 17.
Stacks Image 9124
53. Design, Synthesis and Characterization of Covalent KDM5 Inhibitors
Wright, M., Vazquez-Rodriguez, S., Rogers, C. M., Cribbs, A., Velupillai, S., Philpott, M., Lee, H., Dunford, J. E., Huber, K. V. M., Robers, M. B., Vasta, J. D., Thezenas, M.-L., Bonham, S., Kessler, B., Bennett, J., Fedorov, O., Raynaud, F., Donovan, A., Blagg, J., Bavetsias, V., Oppermann, U., Kawamura, A. and Brennan, P. E.
ChemRxiv, 2018, Preprint.
Angew. Chem. Int. Ed., 2019, 58, 515.
Stacks Image 9118

2018
52. A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL)
Heidenreich, H., Moustakim, M., Schmidt, J., Merk, D., Brennan, P. E., Fedorov, O., Chaikuad, A. and Knapp, S.
J. Med. Chem., 2018, 61, 10929.
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51. Target Identification Using Chemical Probes​
Moustakim, M., Ling Felce, S., Zaarour, N., Farnie, G., McCann, F. E. and Brennan, P. E.
in Methods in Enzymology, 2018, 610, 27.
50. Stereospecific 1,3-H Transfer of Indenols Proceeds via Persistent Ion-Pairs Anchored By NH···Pi Interactions
Ascough, D. M. H., Duarte, F. and Paton, R. S.
ChemRxiv, 2018, Preprint.
J. Am. Chem. Soc.,
2018, 140, 16740.
Stacks Image 9116
49. Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes
Tan, Q. W., Chovatia, P. and Willis, M. C.
Org. Biomol. Chem., 2018, 16, 7797.
Stacks Image 9110
48. Discovery of an MLLT1/3 YEATS Domain Chemical Probe
Moustakim, M., Christott, T., Monteiro, O. P., Bennett, J., Giroud, C., Ward, J., Rogers, C. M., Smith, P., Panagakou, I., Saez, L. D., Ling Felce, S., Gamble, V., Gileadi, C., Halidi, N., Heidenreich, D., Chaikuad, A., Knapp, S., Huber, K. V. M., Farnie, G., Heer, J., Manevski, N., Poda, G., Al-awar, R., Dixon, D. J., Brennan, P. E. and Fedorov, F.
ChemRxiv, 2018, Preprint.
Angew. Chem. Int. Ed.,
2018, 57, 13602.
Stacks Image 9112
47. Enantioselective Silver-Catalyzed Cascade Synthesis of Fused Lactone and Lactam Oxazolines
de la Campa, R., Manzano, R., Calleja, P., Ellis, S. R. and Dixon, D. J.
Org.Lett., 2018, 20, 6033.
Stacks Image 9049
46. Post-translational site-selective protein backbone α-deuteration
Galan, S. R. G., Wickens, J. R., Dadova, J., Ng, W.-L., Zhang, X., Simion, R. A., Quinlan, R., Pires, E., Paton, R. S., Caddick, S., Chudasama, V. and Davis. B. G.
Nat. Chem. Biol., 2018, 14, 955.
Stacks Image 9058
45. Principles and Applications of Fragment-based Drug Discovery for Chemical Probes
Moustakim, M. and Brennan, P. E.
in Chem. Biol. Synth. Enabling Approaches Underst. Biol., RSC, 2018, 114.
44. Bifunctional Iminophosphorane Catalysed Enantioselective Sulfa-Michael Addition of Alkyl Thiols to Alkenyl Benzimidazoles
Formica, M., Sorin, G., Farley, A. J. M., Díaz, J., Paton, R. S. and Dixon, D. J.
Chem. Sci., 2018, 9, 6969.
Stacks Image 9026
43. Photocatalytic Reverse Polarity Povarov Reaction
Leitch, J. A., Fuentes de Arriba, A. L., Tan, J., Hoff, O., Martínez, C. M. and Dixon, D. J.
Chem. Sci., 2018, 9, 6653.
Stacks Image 9015
42. Polyyne formation via skeletal rearrangement induced by atomic manipulation
Pavliček, N., Gawel, N., Kohn, D. R., Majzik, Z., Xiong, Y., Meyer, G., Anderson, H. L. and Gross, L.
Nat. Chem., 2018, 10, 853.
Stacks Image 9008
41. A Bench-Stable Transfer Reagent for the Synthesis of Trifluoromethyl-sulfonimidamides from Sulfinamides
Wright, M., Martinez-Lamenca, C., Leenaerts, J. E., Brennan, P. E., Trabanco, A. A., Oehlrich, D.
J. Org. Chem., 2018, 83, 9510.
Stacks Image 9010
40. A transient self-assembling self-replicator
Colomer, I., Morrow, S. M. and Fletcher S. P.
Nat. Commun., 2018, 9, 2239.
Stacks Image 9204
39. The Plant Cysteine Oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors
White, Mark. D., Kamps, J. A. G., East, S., Taylor Kearney, L. J. and Flashman, E.
J. Biol. Chem., 2018, 293, 11786.
38. Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis
Rabe, P., Kamps, J. A. G., Schofield, C. J. and Lohans, C. T.
Nat. Prod. Rep., 2018, 35, 735.
Stacks Image 8981
37. Synthesis and Applications of Highly Functionalized 1-Halo-3-Substituted Bicyclo[1.1.1]pentanes
Caputo, D. F. J., Arroniz, C., Dürr, A. B., Mousseau, J. J., Stepan, A. F., Mansfield, S. J. and Anderson, E. A.
Chem. Sci., 2018, 9, 5295.
Stacks Image 8975
35. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
Jennings, L. E., Schiedel, M., Hewings, D. S., Picaud, S., Laurin, C. M. C., Bruno, P. A., Bluck, J. P., Scorah, A. R., See, L., Reynolds, J. K., Moroglu, M., Mistry, I. N., Hicks, A., Guzanov, P., Clayton, J., Evans, C., Stazi, G., Biggin, P. C., Mapp. A. K., Hammond, E. M., Humphreys, P. G., Filippakoulous, P., Conway, S. J.
Bioorg. Med. Chem., 2018, 26, 2937.
Stacks Image 8955
34. Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
Ascough, D. M. H., Pupo, G., Ibba, F., Vicini, A. C., Ricci, P., Christensen, K. E., Pfeifer, L. Morphy, J. R., Brown, J. M., Paton, R. S. and Gouverneur, V.
Science, 2018, 360, 638.
Stacks Image 8964
33. An enamine controlling group for rhodium-catalyzed intermolecular hydroacylation
Straker, R. N., Formica, M., Lupton, J. D., Niu, J. and Willis, M. C.
Tetrahedron, 2018, 74, 5408.
Stacks Image 8943
32. Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2
Moustakim, M., Riedel, K., Schuller, M., Gehring, A. P., Monteiro, O. P., Martin, S. P., Fedorov, O., Heer, J., Dixon, D. J., Elkins, J. M., Knapp, S., Bracher, F. and Brennan, P. E.
Bioorg. Med. Chem., 2018, 26, 2965.
Stacks Image 8871
31. Molecular machines for catalysis
van Dijk, L., Tilby, M. J., Szpera, R., Smith, O. A., Bunce, H. A. P. and Fletcher, S. P.
Nature Rev. Chem., 2018, 2, 0117.
Stacks Image 8923
30. Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases
Zhang, D., Markoulides, M. S., Stepanovs, D., Rydzik, A. M., El-Hussein, A., Bon, C., Kamps, J. J. A. G., Umland, K.-D., Collins, P. M., Cahill, S. T., Wanga, D. Y., von Delft, F., Brem, J., McDonough, M. A. and Schofield, C. J.
Bioorg. Med. Chem., 2018, 26, 2928.
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Stacks Image 8935
29. Spironaphthoxazine switchable dyes for biological imaging
Xiong, Y., Vargas Jentzsch, A., Osterrieth, J. W. M., Sezgin, E., Sazanovich, I. W., Reglinski, K., Galiani, S., Parker, A. W., Eggeling, C. and Anderson, H. L.
Chem. Sci., 2018, 9, 3029.
Stacks Image 8907
27. Synthesis of Polyynes Using Dicobalt Masking Groups
Kohn, D. R., Gawel, P., Xiong, Y., Christensen, K. E. and Anderson, H. L.
J. Org. Chem., 2018, 83, 2077.
Stacks Image 8918
26. Detecting Mechanochemical Atropisomerization within an STM Break Junction
Leary, E., Roche, C., Jiang, H., Grace, I., González, M. T., Rubio-Bollinger, G., Romero-Muñiz, C., Xiong, Y., Al-Galiby, Q., Noori, M., Lebedeva, M. A., Porfyrakis, K., Agrait, N., Hodgson, A., Higgins, S. J., Lambert, C. J., Anderson, H. L. and Nichols, R. J
J. Am. Chem. Soc., 2018, 140, 710.
Stacks Image 8916

2017
25. Total synthesis of (−)-himalensine A
Shi, H., Michaelides, I. N., Darses, B., Jakubec, P., Nguyen, Q. N. N., Paton, R. S. and Dixon, D. J.
J. Am. Chem. Soc. 2017, 139, 17755.
Stacks Image 8698
24. Hexafluoroisopropanol as a highly versatile solvent
Colomer, I., Chamberlain, A. E. R., Haughey, M. B., Donohoe, T. J.
Nature Rev. Chem. 2017, 1, 0088.
Stacks Image 9166
23. One-pot, Three-Component Sulfonimidamide Synthesis exploiting the Sulfinylamine Reagent N-Sulfinyltritylamine, TrNSO
Davies, T. Q., Hall, A. and Willis, M. C.
Angew. Chem. Int. Ed. 2017, 56, 14937.
Stacks Image 8717
22. Copper-Catalyzed Synthesis and Applications of Yndiamide
Mansfield, S. J., Christensen, K. E., Thompson, A. L., Ma, K., Jones, M. W., Mekareeya, A. and Anderson​, E. A.
Angew. Chem. Int. Ed. 2017, 56, 14428.
Stacks Image 8723
21. Enantioselective Conjugate Addition Catalyzed by a Copper Phosphoramidite Complex: Computational and Experimental Exploration of Asymmetric Induction
Ardkhean, R.
,  Roth, P. M. C., Maksymowicz, R. M., Curran, A., Peng, Q., Paton, R. S. and Fletcher, S. P.
ACS Catal. 2017, 7, 6729.
Stacks Image 8735
20. Crotonases - Nature's Exceedingly Convertible Catalysts
Lohans, C. T., Wang, D. Y., Wang, J., Hamed, R. B., Schofield, C. J.
ACS Catal. 2017, 7, 6587.
Stacks Image 8729
19. Exploiting Carbonyl Groups to Control Intermolecular Rhodium-Catalyzed Alkene and Alkyne Hydroacylation
Coxon, T. J., Fernandez, M., Barwick-Silk, J., McKay, A. I., Britton, L. E., Weller, A. S., Willis, M. C.
J. Am. Chem. Soc. 2017, 139, 10142.
Stacks Image 8749
18. Visible light photocatalysis of 6π heterocyclization
Münster, N., Parker, N. A., van Dijk, L., Paton, R. S., Smith, M. D.
Angew. Chem. Int. Ed. 2017, 56, 9468.
Stacks Image 8743
17. Unexpected Interactions between Alkyl Straps and Pyridine Ligands in Sulfur-Strapped Porphyrin Nanorings
Roche, C., Lou, Q., Gil-Ramirez, G., Jiang, H.-W., Kohn, D. R., Xiong, Y., Thompson, A. L., Anderson, H. L.
J. Org. Chem. 2017, 82, 7446.
Stacks Image 8761
16. Potential for minimal self-replicating systems in a dynamic combinatorial library of equilibrating imines
Morrow, S. M.
, Bissette, A. J., Fletcher, S. P.
Tetrahedron 2017, 73, 5005.
Stacks Image 8769
15. Transmission of chirality through space and across length scales
Morrow, S. M.
, Bissette, A. J. and Fletcher, S. P.
Nature Nanotechnology 201712, 410.
Stacks Image 8755
14. Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate
Zhang, Z., Smart, T. J., Choi, H., Hardy, F., Lohansa, C. T., Abboud, M. I., Richardson, M. S. W., Paton, R. S., McDonough, M. A. and Schofield, C. J.
Proc. Natl. Acad. Sci. 2017, 114, 4667. 
Stacks Image 8775
13. Neutral iodotriazole foldamers as tetradentate halogen bonding anion receptors
Borissov, A.
, Lim, J. Y. C., Brown, A., Christensen, K. E., Thompson, A. L., Smith, M. D. and Beer, P. D.
Chem. Commun. 2017, 53, 2483.
Stacks Image 8781
12. Discovery of a PCAF Bromodomain Chemical Probe
Moustakim, M.
, Clark, P. G. K., Trulli, L., Fuentes de Arriba, A. L., Ehebauer, M. T., Chaikuad, A., Murphy, E. J., Mendez-Johnson, J., Daniels, D., Hou, C.-F. D., Lin, Y.-H., Walker, J. R., Hui, R., Yang, H., Dorrel, L., Rogers, C. M., Monteiro, O. P., Fedorov, O., Huber, K. V. M., Knapp, S., Heer, J., Dixon, D. J., Brennan, P. E.
Angew. Chem. Int. Ed. 201756, 827. DOI: 10.1002/anie.201610816.
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2016
10. A Cascade Strategy Enables a Total Synthesis of (+/-)-Morphine
Chu, S., Münster, N., Balan, T., Smith. M. D.
Angew. Chem. Int. Ed. 2016, 55, 14306.
Stacks Image 8807
9. Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity
Wright, T. H., Bower, B. J., Chalker, J. M., Bernardes, G. J. L., Wiewiora, R., Ng, W.-L., Raj, R., Faulkner, S., Vallée, M. R. J., Phanumartwiwath, A., Coleman, O. D., Thézénas, M.-L., Khan, M., Galan, S. R. G., Lercher, L., Schombs, M. W., Gerstberger, S., Palm-Espling, M. E., Baldwin, A. J., Kessler, B. M., Claridge, T. D. W., Mohammed, S. and Davis, B. G.
Science 2016, 354, 597.
Stacks Image 8813
8. Chemical Probes and Inhibitors of Bromodomains outside the BET family
Moustakim, M.
, Clark, P. G. K., Hay, D. A., Dixon, D. J. and Brennan, P. E.
Med. Chem. Commun. 2016, 7, 2246.
Stacks Image 8819
7. Photoswitchable Spiropyran Dyads for Biological Imaging
Xiong, Y.
, Rivera-Fuentes, P., Sezgin, E., Jentzsch, A. V., Eggeling, C. and Anderson, H. L.
Org. Lett. 2016, 8, 3666.
Stacks Image 8825
6. Cp2ZrMeCl: A Reagent for Asymmetric Methyl Addition
Garrec, K
. and Fletcher, S. P.
Org. Lett. 2016, 8, 3814.
Stacks Image 8831
5. Recent Applications in Natural Product Synthesis of Dihydrofuran and -pyran Formation by Ring-closing Alkene Metathesis
Jacques, R.
, Pal, R., Parker, N. A., Sear, C. E., Smith, P. W., Ribaucourt, A. and Hodgson, D. M.
Org. Biomol. Chem. 2016, 14, 5875.
Stacks Image 8837
4. Organocatalytic Enantioselective Desymmetrisation
Borissov, A.
, Davies, T. Q., Ellis, S. R., Fleming T. F., Richardson, M. S. W. and Dixon, D. J.
Chem. Soc. Rev. 2016, 45, 5474.
Stacks Image 8843
3. Cascade Polycyclizations in Natural Product Synthesis
Ardkhean, R.
, Caputo, D. F. J., Morrow, S. M., Shi H., Xiong, Y and Anderson, E. A.
Chem. Soc. Rev. 2016, 45, 1557.
Stacks Image 8787

2015
2. Strategic Application and Transformation of ortho-Disubstituted Phenyl and Cyclopropyl Ketones to Expand the Scope of Hydrogen Borrowing Catalysis
Frost, J. R., Cheong, C. B., Akhtar, W. M., Caputo, D. F. J., Stevenson, N. G. and Donohoe, T. J.
J. Am. Chem. Soc. 2015, 137, 15664.
Stacks Image 8855
1. Active-Metal Template Synthesis of a Halogen-Bonding Rotaxane for Anion Recognition
Langton, M. J., Xiong, Y. and Beer, P. D.
Chem. Eur. J. 2015, 21, 18910.
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Stacks Image 8654
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