PUBLICATIONS

Our students have published their research in a wide variety of high-impact scientific journals. Please see below a list of all SBM CDT research publications.

2019
68. Synthesis of Enantioenriched α‐Chiral Bicyclo[1.1.1]pentane​​
Wong, M. L. J., Mousseau, J. J., Mansfield, S. J. and Anderson, E. A.
Org. Lett., 2019, ASAP.
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67. A chemically fuelled self-replicator
Morrow, S. M., Colomer, I. and Fletcher, S. P.
Nat. Commun., 2019, 10, 1011.
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66. Practical and scalable kinetic resolution of BINOLs mediated by a chiral counterion
Jones, B. A., Balan, T., Jolliffe, J. D., Campbell, C. D., Smith, M. D.
Angew. Chem. Int. Ed., 2019, Early View.
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65. Dithiane-Directed Rh(III)-Catalyzed Amidation of Unactivated C(sp3)-H Bonds
Shi, H. and Dixon, D. J.
Chem. Sci., 2019, Advance Article.
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64. The fluorination of C–H bonds: developments and perspectives​
Szpera, R., Moseley, D. F. J., S., Smith, L. B., Sterling, A. J., Gouverneur, V.
Angew. Chem. Int. Ed., 2019, Accepted Article.
63. Primary α-Tertiary Amine Synthesis via α-C–H Functionalization
Vasu, D., Fuentes de Arriba, A. L., Leitch, J. A., de Gombert, A. and Dixon, D. J.
ChemRxiv, 2018, Preprint.
Chem. Sci.,
2019, 10, 3401.
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62. Anion recognition in water by charge-neutral halogen and chalcogen bonding foldamer receptors​
Borissov, A., Marques, I., Lim, J. Y. C., Félix, V., Smith, M. D. and Beer, P. D.
J. Am. Chem. Soc., 2019, 141, 4119.
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61. Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines
Pupo, G., Vicini, A. C., Ascough, D. M. H., Ibba, F., Christensen, K. E., Thompson, A. L., Brown, J. M., Paton, R. S. and Gouverneur, V.
J. Am. Chem. Soc., 2019, 141, 2878.
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60. Conformational Effects on Physical-Organic Descriptors – the Case of Sterimol Steric Parameters​
Brethome, A., Fletcher, S. P., Paton, R. S.
ChemRxiv, 2018, Preprint.
ACS Catal.,
2019, 9, 2313.
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59. Hydrogen bond enabled dynamic kinetic resolution of axially chiral amides mediated by a chiral counterion
Fugard, A. J., Lahdenperä, A. S. K., Tan, J. S. J., Mekareeya, A., Paton, R. S., Smith, M. D.
Angew. Chem. Int. Ed., 2019, 58, 2795.
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58. Chemical epigenetics: the impact of chemical‐ and chemical biology techniques on bromodomain target validation​
Schiedel, M., Moroglu, M., Ascough, D. M. H., Chamberlain, A. E. R., Kamps, J. J. A. G., Sekirnik, A. R., Conway, S. J.
Angew. Chem. Int. Ed., 2019, Accepted Article.
57. Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
Jacques, R., Pullin, R. D. C. and Fletcher, S. P.
ChemRxiv, 2018, Preprint.
Nat. Commun.,
2019, 10, 21.
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56. Data-mining the diaryl(thio)urea conformational landscape: Understanding the contrasting behavior of ureas and thioureas with quantum chemistry
Luchini, G., Ascough, D.M.H., Alegre-Requena, J. V., Gouverneur, V. and Paton, R. S.
Tetrahedron, 2019, 75, 697.
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55. Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by L,D‐Transpeptidases and Serine β‐Lactamase Cysteine Variants
Chan, H. T. H., Lohans, C. T., Malla, T. R., Kumar, K., Kamps, J. J. A. G., McArdle, D. J. B., van Groesen, E., de Munnik, M., Tooke, C. L., Spencer, J., Paton, R. S., Brem, J. and Schofield, C. J.
Angew. Chem. Int. Ed., 2019, 58, 1990.
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54. Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides
Hyde, S., Veliksa, J., Ascough, D. M. H., Szpera, R., Paton, R. S., Gouverneur, V.
Tetrahedron, 2019, 75, 17.
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53. Design, Synthesis and Characterization of Covalent KDM5 Inhibitors
Wright, M., Vazquez-Rodriguez, S., Rogers, C. M., Cribbs, A., Velupillai, S., Philpott, M., Lee, H., Dunford, J. E., Huber, K. V. M., Robers, M. B., Vasta, J. D., Thezenas, M.-L., Bonham, S., Kessler, B., Bennett, J., Fedorov, O., Raynaud, F., Donovan, A., Blagg, J., Bavetsias, V., Oppermann, U., Kawamura, A. and Brennan, P. E.
ChemRxiv, 2018, Preprint.
Angew. Chem. Int. Ed., 2019, 58, 515.
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2018
52. A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL)
Heidenreich, H., Moustakim, M., Schmidt, J., Merk, D., Brennan, P. E., Fedorov, O., Chaikuad, A. and Knapp, S.
J. Med. Chem., 2018, 61, 10929.
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51. Target Identification Using Chemical Probes​
Moustakim, M., Ling Felce, S., Zaarour, N., Farnie, G., McCann, F. E. and Brennan, P. E.
in Methods in Enzymology, 2018, 610, 27.
50. Stereospecific 1,3-H Transfer of Indenols Proceeds via Persistent Ion-Pairs Anchored By NH···Pi Interactions
Ascough, D. M. H., Duarte, F. and Paton, R. S.
ChemRxiv, 2018, Preprint.
J. Am. Chem. Soc.,
2018, 140, 16740.
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49. Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes
Tan, Q. W., Chovatia, P. and Willis, M. C.
Org. Biomol. Chem., 2018, 16, 7797.
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48. Discovery of an MLLT1/3 YEATS Domain Chemical Probe
Moustakim, M., Christott, T., Monteiro, O. P., Bennett, J., Giroud, C., Ward, J., Rogers, C. M., Smith, P., Panagakou, I., Saez, L. D., Ling Felce, S., Gamble, V., Gileadi, C., Halidi, N., Heidenreich, D., Chaikuad, A., Knapp, S., Huber, K. V. M., Farnie, G., Heer, J., Manevski, N., Poda, G., Al-awar, R., Dixon, D. J., Brennan, P. E. and Fedorov, F.
ChemRxiv, 2018, Preprint.
Angew. Chem. Int. Ed.,
2018, 57, 13602.
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47. Enantioselective Silver-Catalyzed Cascade Synthesis of Fused Lactone and Lactam Oxazolines
de la Campa, R., Manzano, R., Calleja, P., Ellis, S. R. and Dixon, D. J.
Org.Lett., 2018, 20, 6033.
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46. Post-translational site-selective protein backbone α-deuteration
Galan, S. R. G., Wickens, J. R., Dadova, J., Ng, W.-L., Zhang, X., Simion, R. A., Quinlan, R., Pires, E., Paton, R. S., Caddick, S., Chudasama, V. and Davis. B. G.
Nat. Chem. Biol., 2018, 14, 955.
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45. Principles and Applications of Fragment-based Drug Discovery for Chemical Probes
Moustakim, M. and Brennan, P. E.
in Chem. Biol. Synth. Enabling Approaches Underst. Biol., RSC, 2018, 114.
44. Bifunctional Iminophosphorane Catalysed Enantioselective Sulfa-Michael Addition of Alkyl Thiols to Alkenyl Benzimidazoles
Formica, M., Sorin, G., Farley, A. J. M., Díaz, J., Paton, R. S. and Dixon, D. J.
Chem. Sci., 2018, 9, 6969.
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43. Photocatalytic Reverse Polarity Povarov Reaction
Leitch, J. A., Fuentes de Arriba, A. L., Tan, J., Hoff, O., Martínez, C. M. and Dixon, D. J.
Chem. Sci., 2018, 9, 6653.
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42. Polyyne formation via skeletal rearrangement induced by atomic manipulation
Pavliček, N., Gawel, N., Kohn, D. R., Majzik, Z., Xiong, Y., Meyer, G., Anderson, H. L. and Gross, L.
Nat. Chem., 2018, 10, 853.
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41. A Bench-Stable Transfer Reagent for the Synthesis of Trifluoromethyl-sulfonimidamides from Sulfinamides
Wright, M., Martinez-Lamenca, C., Leenaerts, J. E., Brennan, P. E., Trabanco, A. A., Oehlrich, D.
J. Org. Chem., 2018, 83, 9510.
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40. A transient self-assembling self-replicator
Colomer, I., Morrow, S. M. and Fletcher S. P.
Nat. Commun., 2018, 9, 2239.
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39. The Plant Cysteine Oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors
White, Mark. D., Kamps, J. A. G., East, S., Taylor Kearney, L. J. and Flashman, E.
J. Biol. Chem., 2018, 293, 11786.
38. Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis
Rabe, P., Kamps, J. A. G., Schofield, C. J. and Lohans, C. T.
Nat. Prod. Rep., 2018, 35, 735.
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37. Synthesis and Applications of Highly Functionalized 1-Halo-3-Substituted Bicyclo[1.1.1]pentanes
Caputo, D. F. J., Arroniz, C., Dürr, A. B., Mousseau, J. J., Stepan, A. F., Mansfield, S. J. and Anderson, E. A.
Chem. Sci., 2018, 9, 5295.
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35. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
Jennings, L. E., Schiedel, M., Hewings, D. S., Picaud, S., Laurin, C. M. C., Bruno, P. A., Bluck, J. P., Scorah, A. R., See, L., Reynolds, J. K., Moroglu, M., Mistry, I. N., Hicks, A., Guzanov, P., Clayton, J., Evans, C., Stazi, G., Biggin, P. C., Mapp. A. K., Hammond, E. M., Humphreys, P. G., Filippakoulous, P., Conway, S. J.
Bioorg. Med. Chem., 2018, 26, 2937.
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34. Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
Ascough, D. M. H., Pupo, G., Ibba, F., Vicini, A. C., Ricci, P., Christensen, K. E., Pfeifer, L. Morphy, J. R., Brown, J. M., Paton, R. S. and Gouverneur, V.
Science, 2018, 360, 638.
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33. An enamine controlling group for rhodium-catalyzed intermolecular hydroacylation
Straker, R. N., Formica, M., Lupton, J. D., Niu, J. and Willis, M. C.
Tetrahedron, 2018, 74, 5408.
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32. Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2
Moustakim, M., Riedel, K., Schuller, M., Gehring, A. P., Monteiro, O. P., Martin, S. P., Fedorov, O., Heer, J., Dixon, D. J., Elkins, J. M., Knapp, S., Bracher, F. and Brennan, P. E.
Bioorg. Med. Chem., 2018, 26, 2965.
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31. Molecular machines for catalysis
van Dijk, L., Tilby, M. J., Szpera, R., Smith, O. A., Bunce, H. A. P. and Fletcher, S. P.
Nature Rev. Chem., 2018, 2, 0117.
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30. Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases
Zhang, D., Markoulides, M. S., Stepanovs, D., Rydzik, A. M., El-Hussein, A., Bon, C., Kamps, J. J. A. G., Umland, K.-D., Collins, P. M., Cahill, S. T., Wanga, D. Y., von Delft, F., Brem, J., McDonough, M. A. and Schofield, C. J.
Bioorg. Med. Chem., 2018, 26, 2928.
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29. Spironaphthoxazine switchable dyes for biological imaging
Xiong, Y., Vargas Jentzsch, A., Osterrieth, J. W. M., Sezgin, E., Sazanovich, I. W., Reglinski, K., Galiani, S., Parker, A. W., Eggeling, C. and Anderson, H. L.
Chem. Sci., 2018, 9, 3029.
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27. Synthesis of Polyynes Using Dicobalt Masking Groups
Kohn, D. R., Gawel, P., Xiong, Y., Christensen, K. E. and Anderson, H. L.
J. Org. Chem., 2018, 83, 2077.
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26. Detecting Mechanochemical Atropisomerization within an STM Break Junction
Leary, E., Roche, C., Jiang, H., Grace, I., González, M. T., Rubio-Bollinger, G., Romero-Muñiz, C., Xiong, Y., Al-Galiby, Q., Noori, M., Lebedeva, M. A., Porfyrakis, K., Agrait, N., Hodgson, A., Higgins, S. J., Lambert, C. J., Anderson, H. L. and Nichols, R. J
J. Am. Chem. Soc., 2018, 140, 710.
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2017
25. Total synthesis of (−)-himalensine A
Shi, H., Michaelides, I. N., Darses, B., Jakubec, P., Nguyen, Q. N. N., Paton, R. S. and Dixon, D. J.
J. Am. Chem. Soc. 2017, 139, 17755.
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24. Hexafluoroisopropanol as a highly versatile solvent
Colomer, I., Chamberlain, A. E. R., Haughey, M. B., Donohoe, T. J.
Nature Rev. Chem. 2017, 1, 0088.
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23. One-pot, Three-Component Sulfonimidamide Synthesis exploiting the Sulfinylamine Reagent N-Sulfinyltritylamine, TrNSO
Davies, T. Q., Hall, A. and Willis, M. C.
Angew. Chem. Int. Ed. 2017, 56, 14937.
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22. Copper-Catalyzed Synthesis and Applications of Yndiamide
Mansfield, S. J., Christensen, K. E., Thompson, A. L., Ma, K., Jones, M. W., Mekareeya, A. and Anderson​, E. A.
Angew. Chem. Int. Ed. 2017, 56, 14428.
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21. Enantioselective Conjugate Addition Catalyzed by a Copper Phosphoramidite Complex: Computational and Experimental Exploration of Asymmetric Induction
Ardkhean, R.
,  Roth, P. M. C., Maksymowicz, R. M., Curran, A., Peng, Q., Paton, R. S. and Fletcher, S. P.
ACS Catal. 2017, 7, 6729.
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20. Crotonases - Nature's Exceedingly Convertible Catalysts
Lohans, C. T., Wang, D. Y., Wang, J., Hamed, R. B., Schofield, C. J.
ACS Catal. 2017, 7, 6587.
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19. Exploiting Carbonyl Groups to Control Intermolecular Rhodium-Catalyzed Alkene and Alkyne Hydroacylation
Coxon, T. J., Fernandez, M., Barwick-Silk, J., McKay, A. I., Britton, L. E., Weller, A. S., Willis, M. C.
J. Am. Chem. Soc. 2017, 139, 10142.
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18. Visible light photocatalysis of 6π heterocyclization
Münster, N., Parker, N. A., van Dijk, L., Paton, R. S., Smith, M. D.
Angew. Chem. Int. Ed. 2017, 56, 9468.
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17. Unexpected Interactions between Alkyl Straps and Pyridine Ligands in Sulfur-Strapped Porphyrin Nanorings
Roche, C., Lou, Q., Gil-Ramirez, G., Jiang, H.-W., Kohn, D. R., Xiong, Y., Thompson, A. L., Anderson, H. L.
J. Org. Chem. 2017, 82, 7446.
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16. Potential for minimal self-replicating systems in a dynamic combinatorial library of equilibrating imines
Morrow, S. M.
, Bissette, A. J., Fletcher, S. P.
Tetrahedron 2017, 73, 5005.
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15. Transmission of chirality through space and across length scales
Morrow, S. M.
, Bissette, A. J. and Fletcher, S. P.
Nature Nanotechnology 201712, 410.
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14. Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate
Zhang, Z., Smart, T. J., Choi, H., Hardy, F., Lohansa, C. T., Abboud, M. I., Richardson, M. S. W., Paton, R. S., McDonough, M. A. and Schofield, C. J.
Proc. Natl. Acad. Sci. 2017, 114, 4667. 
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13. Neutral iodotriazole foldamers as tetradentate halogen bonding anion receptors
Borissov, A.
, Lim, J. Y. C., Brown, A., Christensen, K. E., Thompson, A. L., Smith, M. D. and Beer, P. D.
Chem. Commun. 2017, 53, 2483.
Stacks Image 8781
12. Discovery of a PCAF Bromodomain Chemical Probe
Moustakim, M.
, Clark, P. G. K., Trulli, L., Fuentes de Arriba, A. L., Ehebauer, M. T., Chaikuad, A., Murphy, E. J., Mendez-Johnson, J., Daniels, D., Hou, C.-F. D., Lin, Y.-H., Walker, J. R., Hui, R., Yang, H., Dorrel, L., Rogers, C. M., Monteiro, O. P., Fedorov, O., Huber, K. V. M., Knapp, S., Heer, J., Dixon, D. J., Brennan, P. E.
Angew. Chem. Int. Ed. 201756, 827. DOI: 10.1002/anie.201610816.
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2016
10. A Cascade Strategy Enables a Total Synthesis of (+/-)-Morphine
Chu, S., Münster, N., Balan, T., Smith. M. D.
Angew. Chem. Int. Ed. 2016, 55, 14306.
Stacks Image 8807
9. Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity
Wright, T. H., Bower, B. J., Chalker, J. M., Bernardes, G. J. L., Wiewiora, R., Ng, W.-L., Raj, R., Faulkner, S., Vallée, M. R. J., Phanumartwiwath, A., Coleman, O. D., Thézénas, M.-L., Khan, M., Galan, S. R. G., Lercher, L., Schombs, M. W., Gerstberger, S., Palm-Espling, M. E., Baldwin, A. J., Kessler, B. M., Claridge, T. D. W., Mohammed, S. and Davis, B. G.
Science 2016, 354, 597.
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8. Chemical Probes and Inhibitors of Bromodomains outside the BET family
Moustakim, M.
, Clark, P. G. K., Hay, D. A., Dixon, D. J. and Brennan, P. E.
Med. Chem. Commun. 2016, 7, 2246.
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7. Photoswitchable Spiropyran Dyads for Biological Imaging
Xiong, Y.
, Rivera-Fuentes, P., Sezgin, E., Jentzsch, A. V., Eggeling, C. and Anderson, H. L.
Org. Lett. 2016, 8, 3666.
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6. Cp2ZrMeCl: A Reagent for Asymmetric Methyl Addition
Garrec, K
. and Fletcher, S. P.
Org. Lett. 2016, 8, 3814.
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5. Recent Applications in Natural Product Synthesis of Dihydrofuran and -pyran Formation by Ring-closing Alkene Metathesis
Jacques, R.
, Pal, R., Parker, N. A., Sear, C. E., Smith, P. W., Ribaucourt, A. and Hodgson, D. M.
Org. Biomol. Chem. 2016, 14, 5875.
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4. Organocatalytic Enantioselective Desymmetrisation
Borissov, A.
, Davies, T. Q., Ellis, S. R., Fleming T. F., Richardson, M. S. W. and Dixon, D. J.
Chem. Soc. Rev. 2016, 45, 5474.
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3. Cascade Polycyclizations in Natural Product Synthesis
Ardkhean, R.
, Caputo, D. F. J., Morrow, S. M., Shi H., Xiong, Y and Anderson, E. A.
Chem. Soc. Rev. 2016, 45, 1557.
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2015
2. Strategic Application and Transformation of ortho-Disubstituted Phenyl and Cyclopropyl Ketones to Expand the Scope of Hydrogen Borrowing Catalysis
Frost, J. R., Cheong, C. B., Akhtar, W. M., Caputo, D. F. J., Stevenson, N. G. and Donohoe, T. J.
J. Am. Chem. Soc. 2015, 137, 15664.
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1. Active-Metal Template Synthesis of a Halogen-Bonding Rotaxane for Anion Recognition
Langton, M. J., Xiong, Y. and Beer, P. D.
Chem. Eur. J. 2015, 21, 18910.
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Department of Chemistry
Chemistry Research Laboratory
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