P4. Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma Cruzi.
Laurin, C., Bluck, J., Chan, A., Keller, M., Boczek, A., Scorah, A., See, K. F. L., Jennings, L., Hewings, D., Woodhouse, F., Schiedel, M., Humphreys, P., Biggin, P. and Conway, S. J.
ChemRxiv, 2020, Preprint.

P3. autodE: Automated Calculation of Reaction Energy Profiles – Application to Organic and Organometallic Reactions.
Young, T., Silcock, J., Sterling, A. and Duarte, F.
ChemRxiv, 2020, Preprint.

P2. Controlling Intramolecular Interactions in the Design of Selective, High-Affinity, Ligands for the CREBBP Bromodomain.
Brand, M., Clayton, J., Moroglu, M., Schiedel, M., Picaud, S., Bluck, J., Skwarska, A., Chan, A., Laurin, C., Scorah, A., See, L., Rooney, T., Fedorov, O., Perell, G., Kalra, P., Cortopassi, W., Christensen, K., Cooper, R., Patom, R., Pomerantz, W., Biggin, P., Hammond, E. M., Filippakopoulos, P. and Conway, S. J.
ChemRxiv, 2020, Preprint.

P1. Mechanistic Investigation of Rh(I)-Catalyzed Asymmetric Suzuki-Miyaura Coupling with Racemic Allyl Halides
van Dijk, L., Ardkhean, R., Sidera, M., Karabiyikoglu, S., Sari, O., Claridge, T. D. W., Paton, R. S. and Fletcher, S. P.
ChemRxiv, 2019, Preprint.

138. A Single‐Stranded DNA‐Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks.
Bassi, G.,Favalli, N., Vuk, M., Catalano, M., Martinelli, A., Trenner, A., Porro, A., Yang, S., Tham, C. L., Moroglu, M., Yue, W. W., Conway, S. J., Vogt, P. K., Sartori, A. A., Scheuermann, J. and Neri, D.
Adv. Sci., 2020, Early View.

137. Synthesis and Structure–Activity Relationship of Dehydrodieugenol B Neolignans against Trypanosoma cruzi.
Sear, C. E., Pieper, P., Amaral, M., Romanelli, M. M., Costa-Silva, T. A., Haugland, M. M., Tate, J. A., Lago, J. H. G., Tempone, A. G. and Anderson, E. A.
ACS Infect. Dis., 2020, Article ASAP.

136. Enzymatic Kinetic Resolution by Addition of Oxygen.
Harwood, L. A., Wong, L. L. and Robertson, J.
Angew. Chem. Int. Ed., 2020, Accepted Article.

135. Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich’s ataxia patient cells.
Vilema-Enríquez, G., Quinlan, R., Kilfeather, P., Mazzone, R., Saqlain, S., Molino del Barrio, I., Donato, A., Corda, G., Li, F., Vedadi, M., Németh, A. H., Brennan, P. E. and Wade-Martins, R.
J. Biol. Chem., 2020, In Press.

134. The 2‐Pyridyl Problem: Challenging Nucleophiles in Cross‐Coupling Arylations.
Cook, X. F., de Gombert, A., McKnight, J., Pantaine, L. and Willis, M. C.
Angew. Chem. Int. Ed., 2020, Accepted Article.

133. α-Tertiary Dialkyl Ether Synthesis via Reductive Photocatalytic α-Functionalization of Alkyl Enol Ethers.
Leitch, J. A., Rossolini, T., Rogova, T. and Dixon, D. J.
ChemRxiv, 2020, Preprint.
ACS Catal., 2020, 10, 11430.

132. Bifunctional Iminophosphorane Superbase Catalysis: Applications in Organic Synthesis.
Formica, M., Rozsar, D., Su, G., Farley, A. and Dixon, D. J.
Acc. Chem. Res., 2020, 53, 2235.

131. Visible light mediated heterocycle functionalization via a geometrically interrupted [2+2] cycloaddition.
Popescu, M., Mekareeya, A., Alegre-Requena, J., Paton, R. and Smith, M. D.
Angew. Chem. Int. Ed., 2020, Early View.

130. Reverse Polarity Reductive Functionalization of Tertiary Amides via a Dual Iridium-Catalyzed Hydrosilylation and Single Electron Transfer Strategy.
Rogova, T., Gabriel, P., Zavitsanou, S., Leitch, J. A., Duarte, F. and Dixon, D. J.
ChemRxiv, 2020, Preprint.
ACS Catal., 2020, 10, 11438.

129. Harnessing Sulfinyl Nitrenes: A Unified One-Pot Synthesis of Sulfoximines and Sulfonimidamides.
Davies, T. Q., Tilby, M. J., Ren, J., Parker, N., Skolc, D., Hall, A., Duarte, F. and Willis, M. C.
J. Am. Chem. Soc., 2020, 142, 15445.

128. Super-resolution RESOLFT microscopy of lipid bilayers using a fluorophore-switch dyad.
Frawley, A., Wycisk, V., Xiong, Y., Galiani, S., Sezgin, E., Urbančič, I., Jentzsch, A., Leslie, K., Eggeling, C. and Anderson, H. L.
Chem. Sci., 2020, 11, 8955.

127. Rhodium catalysed C-3/5 methylation of pyridines using temporary dearomatisation.
Grozavu, A., Hepburn, H., Bailey E., Lindsay-Scott, P. and Donohoe, T.J.
Chem. Sci., 2020, 11, 8595.

126. A Modular and Divergent Approach to Spirocyclic Pyrrolidines.
Shennan, B., Smith, P., Ogura, Y. and Dixon, D. J.
Chem. Sci., 2020, 11, 10354.

125. Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C–O Cross-Coupling.
Szpera, R., Isenegger, P. G., Ghosez, M., Straathof, N., Cookson, R., Blakemore, D., Richardson, P. and Gouverneur, V.
Org. Lett., 2020, 22, 6573.

124. Catalytic Reductive Functionalization of Tertiary Amides using Vaska’s Complex: Synthesis of Complex Tertiary Amine Building Blocks and Natural Products.
Matheau-Raven, D., Gabriel, P., Leitch, J. A., Almehmadi, Y. A., Yamazaki, K. and Dixon, D. J.
ACS Catal., 2020, 10, 8880.

123. Coupled metabolic cycles allow out‐of‐equilibrium autopoietic vesicle replication.
Engwerda, A., Southworth, J., Lebedeva, M., Scanes, R., Kukura, P. and Fletcher, S. P.
Angew. Chem. Int. Ed., 2020, Early View.

122. Selective fragments for the CREBBP bromodomain identified from an Encoded Self‑Assembly Chemical Library.
Catalano, M., Moroglu, M., Balbi, P., Mazzieri, F., Clayton, J., Andrews, K. H., Bigatti, M., Scheuermann, J., Conway, S. J. and Neri, D.
ChemMedChem, 2020, 15, 1752.

121. A Heck reaction/photochemical alkene isomerization sequence to prepare functionalized quinolines.
Kelly, A., Hoffman, J. B., Hoff, O., Walker, J., Werrel, S. and Donohoe, T. J.
Tetrahedron, 2020, 76, 131396.

120. Controlling gene expression with light: a multidisciplinary endeavour.
Hartmann, D., Smith, J., Mazzotti, G., Chowdhry, R. and Booth, M. J.
Biochem Soc Trans, 2020, 48, 1645.

119. Synthesis of Cyclo[18]carbon via Debromination of C₁₈Br₆.
Scriven, L. M., Kaiser, K., Schulz, F., Sterling, A. J., Woltering, S. L., Gawel, P., Christensen, K. E., Anderson, H. L. and Gross, L.
J. Am. Chem. Soc., 2020, 142, 12921.

118. Atropisomerism in diarylamines: structural requirements and mechanisms of conformational interconversion.
Costil, R., Sterling, A. J., Duarte, F. and Clayden, J.
Angew. Chem. Int. Ed., 2020, 59, 18670.

117. Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of γ-Fluoroamines.
Ascough, D. M. H., Roagna, G., Ibba, F., Vicini, A., Fontana, A., Christensen, K. E., Peschiulli, A., Oehlrich, D., Misale, A., Trabanco, A. A., Paton, R. S., Pupo, G. and Gouverneur V.
J. Am. Chem. Soc., 2020, 142, 14045.

116. Single‐molecule observation of intermediates in bioorthogonal 2‐cyanobenzothiazole chemistry.
Qing, Y., Liu, M..D., Hartmann, D., Zhou, L., Ramsay, W..J. and Bayley, H.
Angew. Chem. Int. Ed., 2020, 59, 15711.

115. BIMP Catalyzed 1,3-Prototropic Shift for the Highly Enantioselective Synthesis of Conjugated Cyclohexenones.
Golec, J., Carter, E., Ward, J., Whittingham, W., Simon, L., Paton, R. and Dixon, D. J.
ChemRxiv, 2020, Preprint.
Angew. Chem. Int. Ed., 2020, 59, 17417.

114. Structure-activity relationship study of cytotoxic neolignan derivatives using multivariate analysis and computation-aided drug design.
de Sousa, F. S., Baldim, J. L., Azevedo, R. A., Figueiredo, C. R., Pieper, P., Sear, C. E., Anderson, E. A. and Lago, J. H. G.
Bioorg. Med. Chem. Lett., 2020, 30, 127349.

113. Reversible photo-control over transmembrane anion transport using visible-light responsive supramolecular carriers.
Kerckhoffs, A. and Langton, M. J.
ChemRxiv, 2020, Preprint.
Chem. Sci., 2020, 11, 6325.

112. Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction.
Darlot, B., Eaton, J. R. O., Geis-Asteggiante, L., Yakala, G. K., Karuppanan, K., Davies, G., Robinson, C. V., Kawamura, A. and Bhattacharya, S.
J. Biol. Chem., 2020, 295, 10926.

111. α‐Amidoaldehydes as substrates in rhodium‐catalyzed intermolecular alkyne hydroacylation: The synthesis of α‐amidoketones.
Pal, R., O'Brien, S. and Willis, M. C.
Chem. Eur. J., 2020, 26, 11710.

110. Organophotochemical S_NAr Reactions of Mildly Electron‐Poor Fluoroarenes.
Sheridan, T., Yayla, H., Lian, Y., Genovino, J., Monck, N. and Burton, J. W.
Eur. J. Org. Chem., 2020, 2766.

109. Synthesis of All-carbon Disubstituted Bicyclo[1.1.1]pentanes by Iron-Catalyzed Kumada Cross-Coupling.
Nugent, J., Shire, B., Caputo, D. F. J., Pickford, H. D., Nightingale, F., Houlsby, I. T. T., Mousseau, J. J. and Anderson, E. A.
Angew. Chem. Int. Ed., 2020, 59, 11866.

108. Control of Absolute Stereochemistry in Transition‐Metal‐Catalyzed Hydrogen Borrowing Reactions.
Kwok, T., Hoff, O., Armstrong, R. J. and Donohoe, T. J.
Chem. Eur. J., 2020, 26, 12912.

107. Consecutive 5′- and 3′-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response.
Epple, S., Thorpe, C., Baker, Y. R., El-Sagheer, A. H. and Brown, T.
Chem. Commun., 2020, 56, 5496.

106. Transmembrane anion transport mediated by halogen bonding and hydrogen bonding triazole anionophores.
Bickerton, L. E. E., Sterling, A.J., Beer, P. D., Duarte, F. and Langton, M. J.
Chem. Sci., 2020, 11, 4722.

105. Rationalizing the diverse reactivity of [1.1.1]propellane through sigma-pi-delocalization.
Sterling, A. J., Durr, A.B., Smith, R.C., Anderson, E.A. and Duarte, F.
ChemRxiv, 2019, Preprint.
Chem. Sci., 2020, 11, 4895.

104. Enantiomerically Enriched Tetrahydropyridine Allyl Chlorides.
Karabiyikoglu, S., Brethomé, A., Palacin, T., Paton, R., and Fletcher, S. P.
ChemRxiv, 2019, Preprint.
Chem. Sci., 2020, 11, 4125.

103. An Asymmetric Suzuki–Miyaura Approach to Prostaglandins: Synthesis of Tafluprost.
Kucera, R., Goetzke, F. W. and Fletcher, S. P.
Org. Lett. 2020, 22, 2991.

102. A hydrogen borrowing annulation strategy for the stereocontrolled synthesis of saturated aza-heterocycles.
Chamberlain, A. E. R., Paterson, K. J., Armstrong, R. J., Twin, H. C. and Donohoe, T. J.
Chem. Commun., 2020, 56, 3563.

101. Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis.
Cheang, D. M. J., Armstrong, R. J., Akhtar, W. M. and Donohoe, T. J.
Chem. Commun., 2020, 56, 3543.

100. Double and triple ionization of isocyanic acid.
Eland, J.H.D., Squibb, R.J., Sterling, A.J., Wallner, M., Hult Roos, A., Andersson, J., Axelsson, V., Johansson, E., Teichter, A., Stranges, S., Brunetti, B., Dyke, J.M., Duarte, F. and Feifel, R.
arRxiv, 2019, Preprint.
Sci. Rep., 2020, 10, 2288.

99. Mechanistic Studies of the Palladium-Catalyzed Desulfinative Cross-Coupling of Aryl Bromides and (Hetero)Aryl Sulfinate Salts.
Gombert, A., McKay, A. I., Davis, C. J., Wheelhouse, K. M. and Willis M. C.
J. Am. Chem. Soc., 2020, 142, 3564.

98. A Modular, Enantioselective Synthesis of Resolvins D3, E1, and Hybrids.
Urbitsch, F., Elbert, B. L., Llaveria, J., Streatfeild, P. E. and Anderson, E. A.
Org. Lett., 2020, 22, 1510.

97. Synthesis of the cyclopentane core of pepluanin A.
Shepherd, E. D., Hallside, M. S., Sutro, J. L., Thompson, S., Hutchings, M. and Burton, J. W.
Tetrahedron, 2020, 76, 130981.

96. Chemo- and Regioselective Synthesis of Acyl-Cyclohexenes by a Tandem Acceptorless Dehydrogenation-[1,5]-Hydride Shift Cascade.
Smith, L. B., Armstrong, R. J., Matheau-Raven, D. and Donohoe, T. J.
J. Am. Chem. Soc., 2020, 142, 2514.

95. α-Amino Radicals via Photocatalytic Single-Electron Reduction of Imine Derivatives.
Leitch, J. A., Rossolini, T., Rogova, T., Maitland, J. A. P. and Dixon, D. J.
ACS Catal., 2020, 10, 2009.

94. Bicyclic Lactams Derived from Serine or Cysteine and 2-Methylpropanal.
Bagum, H., Shire, B. R., Christensen, K. E., Genov, M., Pretsch, S., Pretsch, D. and Moloney, M. G.
Synlett, 2020, 31, 378.

93. ¹⁸F-Trifluoromethanesulfinate Enables Direct C–H ¹⁸F-Trifluoromethylation of Native Aromatic Residues in Peptides.
Kee, C. W., Tack, O., Guibbal, F., Wilson, T. C., Isenegger, P. G., Imiołek, M., Verhoog, S., Tilby, M., Boscutti, G., Ashworth, S., Chupin, J., Kashani, R., Poh, A. W. J., Sosabowski, J. K., Macholl, S., Plisson, C., Cornelissen, B., Willis, M. C., Passchier, J., Davis, B. G. and Gouverneur, V.
J. Am. Chem. Soc., 2020, 142, 1180.

92. Dearomative Photocatalytic Construction of Bridged 1,3-Diazepanes.
Leitch, J., Rogova, T., Duarte, F. and Dixon, D. J.
ChemRxiv, 2019, Preprint.
Angew. Chem. Int. Ed., 2020, 59, 4121.

91. Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.
Ni, X., Heidenreich, D., Christott, T., Bennett, J., Moustakim, M., Brennan, P.E., Fedorov, O., Knapp, S. and Chaikuad, A. 
ACS Med. Chem. Lett., 2019, 10, 1661.

90. Iridium-Catalyzed Reductive Coupling of Grignard Reagents and Tertiary Amides.
Gabriel, P., Xie, L-G. and Dixon, D. J.
Org. Synth., 2019, 96, 511.

89. Synthesis of highly fluorinated arene complexes of [Rh(chelating phosphine)]+ cations, and their use in synthesis and catalysis.
McKay, A., Barwick–Silk, J., Savage, M., Willis, M. C. and Weller, A. S.
Chem. Eur. J., 2020, 26, 2883.

88. ¹⁹F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode.
Leśniak, R. K., Rydzik, A. M., Kamps, J.J.A.G., Kahn, A., Hopkinson, R.J., Schofield, C.J. and Claridge, T. D. W.
Chem. Commun., 2019, 55, 14717.

87. How formaldehyde reacts with amino acids.
Kamps, J.J.A.G., Hopkinson, R.J., Schofield, C.J. and Claridge, T. D. W.
Commun Chem, 2019, 2, 126.

86. Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase.
Wilkinson, I. V. L., Reynolds, J. K., Galan, S. R. G., Vuorinen, A., Sills, A. J., Pires, E., Wynne, G. M., Wilson, F. X., Russell, A. J.
Bioorg. Chem., 2020, 94, 103395.

85. Synthesis of Cyclic Alkenyl Dimethylsiloxanes from Alkynyl Benzyldimethylsilanes and Application in Polyene Synthesis
Gudmundsson, H. G., Kuper, C. J., Cornut, D., Urbitsch, F., Elbert, B. and Anderson, E. A.
J. Org. Chem., 2019, 84, 14868.

84. Convergent Total Syntheses of (−)‐Rubriflordilactone B and (−)‐pseudo‐Rubriflordilactone B
Mohammad, M., Chintalapudi, V., Carney, J. M., Mansfield, S. J., Sanderson, P., Christensen, K. E. and Anderson, E. A.
Angew. Chem. Int. Ed., 2019, 58, 18177.

83. Highly enantioselective rhodium-catalyzed cross-coupling of boronic acids and racemic allyl halides.
González, J., van Dijk, L., Goetzke, F.W. and Fletcher, S.P.
Nature Protocols, 2019, 14, 2972.

82. A General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis
Nugent, J., Arroniz, C., Shire, B. R., Sterling, A. J., Pickford, H. D., Wong, M. L. J., Mansfield, S. J., Caputo, D. F. J., Owen, B., Mousseau, J. J., Duarte, F. and Anderson, E. A.
ChemRxiv, 2019, Preprint.
ACS Catal., 2019, 9, 9568.

81. Desymmetrization of Meso-bisphosphates via Rhodium Catalyzed Asymmetric Allylic Arylation
Jacques, R., Hell, A., Pullin, R. and Fletcher, S.
Tetrahedron, 2019, 75, 130560.

80. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
Krajnc, A., Brem, J., Hinchliffe, P., Calvopiña, K., Panduwawala, T.D., Lang, P.A., Kamps, J.J.A.G., Tyrrell, J.M, Widlake, E., Saward, B.G., Walsh, T.R, Spencer, J., and Schofield, C.J.
J. Med. Chem. 2019, 62, 8544.

79. Modular Sulfondiimine Synthesis Using a Stable Sulfinylamine Reagent
Zhang, Z.-X., Davies, T. Q., Willis, M. C.
J. Am. Chem. Soc., 2019, 141, 13022.

78. Iridium-Catalyzed Aza-Spirocyclization of Indole-Tethered Amides: An Interrupted Pictet–Spengler Reaction
Gabriel, P., Gregory, A. W., Dixon, D. J.
Org. Lett., 2019, 21, 6658.

77. Retooling Asymmetric Conjugate Additions for Sterically Demanding Substrates with an Iterative Data-Driven Approach
Brethome, A. V., Paton, R. S. and Fletcher, S. P.
ChemRxiv, 2019, Preprint.
ACS Catal., 2019, 9, 7179.

76. Rhodium-catalysed vinyl 1,4-conjugate addition coupled with Sharpless asymmetric dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin-4
Richardson, M. S. W., Tame, C. J., Poole, D. L. and Donohoe, T. J.
Chem. Sci., 2019, 10, 6336.

75. Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications
Thorpe, C., Epple, S., Woods, B., El-Sagheer, A. H. and Brown, T.
Org. Biomol. Chem., 2019, 17, 5341.

74. Intramolecular Aldol Ring Closures of Cysteine Derivatives Leading to Densely Functionalised Pyroglutamates
Almahli, H., Jimenez, N. C. and Moloney, M. G.
Synlett, 2019, 30, 1237.

73. Total Synthesis of Berkeleylactone A
Ferko, B., Zeman, M., Formica, M., Veselý, S., Doháňošová, J., Moncol, J., Olejníková, P., Berkes, D., Jakubec, P., Dixon, D. J. and Caletkova, O.
J. Org. Chem., 2019, 84, 7159.

72. Dehydrodieugenol B derivatives as antiparasitic agents: Synthesis and biological activity against Trypanosoma cruzi
Ferreira, D. D., Sousa, F. S., Costa-Silva, T. A., Reimão, J. Q., Torrecilhas, A. C., Johns, D. M., Sear, C. E., Honorio, K. H., Lago, J. H. G., Anderson, E. A. and Tempone, A. G.
Eur. J. Med. Chem., 2019, 176, 162.

71. A General Copper-Catalyzed Synthesis of Ynamides from 1,2-Dichloroenamides​
Mansfield, S. J., Smith, R. C., Yong, J. R. J., Garry, O. L. and Anderson, E. A.
Org. Lett., 2019, 21, 2918.

70. A halogen-bonding foldamer molecular film for selective reagentless anion sensing in water
Hein, R., Borissov, A., Smith, M. D., Beer, P. D. and Davis, J. J
Chem. Commun., 2019, 55, 4849.

69. Synthesis of Enantioenriched α‐Chiral Bicyclo[1.1.1]pentane​​
Wong, M. L. J., Mousseau, J. J., Mansfield, S. J. and Anderson, E. A.
Org. Lett., 2019, 21, 2408.

68. A chemically fuelled self-replicator
Morrow, S. M., Colomer, I. and Fletcher, S. P.
Nat. Commun., 2019, 10, 1011.

67. Practical and scalable kinetic resolution of BINOLs mediated by a chiral counterion
Jones, B. A., Balan, T., Jolliffe, J. D., Campbell, C. D., Smith, M. D.
Angew. Chem. Int. Ed., 2019, 58, 4596.

66. Dithiane-Directed Rh(III)-Catalyzed Amidation of Unactivated C(sp3)-H Bonds
Shi, H. and Dixon, D. J.
Chem. Sci., 2019, 10, 3733.

65. The fluorination of C–H bonds: developments and perspectives​
Szpera, R., Moseley, D. F. J., S., Smith, L. B., Sterling, A. J., Gouverneur, V.
Angew. Chem. Int. Ed., 2019, 58, 14824.

64. Primary α-Tertiary Amine Synthesis via α-C–H Functionalization
Vasu, D., Fuentes de Arriba, A. L., Leitch, J. A., de Gombert, A. and Dixon, D. J.
ChemRxiv, 2018, Preprint.
Chem. Sci., 2019, 10, 3401.

63. Anion recognition in water by charge-neutral halogen and chalcogen bonding foldamer receptors​
Borissov, A., Marques, I., Lim, J. Y. C., Félix, V., Smith, M. D. and Beer, P. D.
J. Am. Chem. Soc., 2019, 141, 4119.

62. Chemical Probes​
Donner, A., King, H., Brennan, P. E., Moustakim, M. and Zuercher, W. J.
in Epigenetic Drug Discovery, 2019, 133.

61. Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines
Pupo, G., Vicini, A. C., Ascough, D. M. H., Ibba, F., Christensen, K. E., Thompson, A. L., Brown, J. M., Paton, R. S. and Gouverneur, V.
J. Am. Chem. Soc., 2019, 141, 2878.

60. Conformational Effects on Physical-Organic Descriptors – the Case of Sterimol Steric Parameters​
Brethome, A., Fletcher, S. P., Paton, R. S.
ChemRxiv, 2018, Preprint.
ACS Catal., 2019, 9, 2313.

59. Hydrogen bond enabled dynamic kinetic resolution of axially chiral amides mediated by a chiral counterion
Fugard, A. J., Lahdenperä, A. S. K., Tan, J. S. J., Mekareeya, A., Paton, R. S., Smith, M. D.
Angew. Chem. Int. Ed., 2019, 58, 2795.

58. Chemical epigenetics: the impact of chemical‐ and chemical biology techniques on bromodomain target validation​
Schiedel, M., Moroglu, M., Ascough, D. M. H., Chamberlain, A. E. R., Kamps, J. J. A. G., Sekirnik, A. R., Conway, S. J.
Angew. Chem. Int. Ed., 2019, 58, 17930.

57. Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
Jacques, R., Pullin, R. D. C. and Fletcher, S. P.
ChemRxiv, 2018, Preprint.
Nat. Commun., 2019, 10, 21.

56. Data-mining the diaryl(thio)urea conformational landscape: Understanding the contrasting behavior of ureas and thioureas with quantum chemistry
Luchini, G., Ascough, D.M.H., Alegre-Requena, J. V., Gouverneur, V. and Paton, R. S.
Tetrahedron, 2019, 75, 697.

55. Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by L,D‐Transpeptidases and Serine β‐Lactamase Cysteine Variants
Chan, H. T. H., Lohans, C. T., Malla, T. R., Kumar, K., Kamps, J. J. A. G., McArdle, D. J. B., van Groesen, E., de Munnik, M., Tooke, C. L., Spencer, J., Paton, R. S., Brem, J. and Schofield, C. J.
Angew. Chem. Int. Ed., 2019, 58, 1990.

54. Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides
Hyde, S., Veliksa, J., Ascough, D. M. H., Szpera, R., Paton, R. S., Gouverneur, V.
Tetrahedron, 2019, 75, 17.

53. Design, Synthesis and Characterization of Covalent KDM5 Inhibitors
Wright, M., Vazquez-Rodriguez, S., Rogers, C. M., Cribbs, A., Velupillai, S., Philpott, M., Lee, H., Dunford, J. E., Huber, K. V. M., Robers, M. B., Vasta, J. D., Thezenas, M.-L., Bonham, S., Kessler, B., Bennett, J., Fedorov, O., Raynaud, F., Donovan, A., Blagg, J., Bavetsias, V., Oppermann, U., Kawamura, A. and Brennan, P. E.
ChemRxiv, 2018, Preprint.
Angew. Chem. Int. Ed., 2019, 58, 515.

52. A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL)
Heidenreich, H., Moustakim, M., Schmidt, J., Merk, D., Brennan, P. E., Fedorov, O., Chaikuad, A. and Knapp, S.
J. Med. Chem., 2018, 61, 10929.

51. Target Identification Using Chemical Probes​
Moustakim, M., Ling Felce, S., Zaarour, N., Farnie, G., McCann, F. E. and Brennan, P. E.
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50. Stereospecific 1,3-H Transfer of Indenols Proceeds via Persistent Ion-Pairs Anchored By NH···Pi Interactions
Ascough, D. M. H., Duarte, F. and Paton, R. S.
ChemRxiv, 2018, Preprint.
J. Am. Chem. Soc., 2018, 140, 16740.

49. Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes
Tan, Q. W., Chovatia, P. and Willis, M. C.
Org. Biomol. Chem., 2018, 16, 7797.

48. Discovery of an MLLT1/3 YEATS Domain Chemical Probe
Moustakim, M., Christott, T., Monteiro, O. P., Bennett, J., Giroud, C., Ward, J., Rogers, C. M., Smith, P., Panagakou, I., Saez, L. D., Ling Felce, S., Gamble, V., Gileadi, C., Halidi, N., Heidenreich, D., Chaikuad, A., Knapp, S., Huber, K. V. M., Farnie, G., Heer, J., Manevski, N., Poda, G., Al-awar, R., Dixon, D. J., Brennan, P. E. and Fedorov, F.
ChemRxiv, 2018, Preprint.
Angew. Chem. Int. Ed., 2018, 57, 13602.

47. Enantioselective Silver-Catalyzed Cascade Synthesis of Fused Lactone and Lactam Oxazolines
de la Campa, R., Manzano, R., Calleja, P., Ellis, S. R. and Dixon, D. J.
Org.Lett., 2018, 20, 6033.

46. Post-translational site-selective protein backbone α-deuteration
Galan, S. R. G., Wickens, J. R., Dadova, J., Ng, W.-L., Zhang, X., Simion, R. A., Quinlan, R., Pires, E., Paton, R. S., Caddick, S., Chudasama, V. and Davis. B. G.
Nat. Chem. Biol., 2018, 14, 955.

45. Principles and Applications of Fragment-based Drug Discovery for Chemical Probes
Moustakim, M. and Brennan, P. E.
in Chem. Biol. Synth. Enabling Approaches Underst. Biol., RSC, 2018, 114.

44. Bifunctional Iminophosphorane Catalysed Enantioselective Sulfa-Michael Addition of Alkyl Thiols to Alkenyl Benzimidazoles
Formica, M., Sorin, G., Farley, A. J. M., Díaz, J., Paton, R. S. and Dixon, D. J.
Chem. Sci., 2018, 9, 6969.

43. Photocatalytic Reverse Polarity Povarov Reaction
Leitch, J. A., Fuentes de Arriba, A. L., Tan, J., Hoff, O., Martínez, C. M. and Dixon, D. J.
Chem. Sci., 2018, 9, 6653.

42. Polyyne formation via skeletal rearrangement induced by atomic manipulation
Pavliček, N., Gawel, N., Kohn, D. R., Majzik, Z., Xiong, Y., Meyer, G., Anderson, H. L. and Gross, L.
Nat. Chem., 2018, 10, 853.

41. A Bench-Stable Transfer Reagent for the Synthesis of Trifluoromethyl-sulfonimidamides from Sulfinamides
Wright, M., Martinez-Lamenca, C., Leenaerts, J. E., Brennan, P. E., Trabanco, A. A., Oehlrich, D.
J. Org. Chem., 2018, 83, 9510.

40. A transient self-assembling self-replicator
Colomer, I., Morrow, S. M. and Fletcher S. P.
Nat. Commun., 2018, 9, 2239.

39. The Plant Cysteine Oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors
White, Mark. D., Kamps, J. A. G., East, S., Taylor Kearney, L. J. and Flashman, E.
J. Biol. Chem., 2018, 293, 11786.

38. Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis
Rabe, P., Kamps, J. A. G., Schofield, C. J. and Lohans, C. T.
Nat. Prod. Rep., 2018, 35, 735.

37. Synthesis and Applications of Highly Functionalized 1-Halo-3-Substituted Bicyclo[1.1.1]pentanes
Caputo, D. F. J., Arroniz, C., Dürr, A. B., Mousseau, J. J., Stepan, A. F., Mansfield, S. J. and Anderson, E. A.
Chem. Sci., 2018, 9, 5295.

36. Rh(DPEPhos)-Catalyzed Alkyne Hydroacylation using β-Carbonyl Substituted Aldehydes. Mechanistic Insight Leads to Low Catalyst Loadings that Enables Selective Catalysis on Gram-Scale
Barwick-Silk, J., Hardy, S., Willis, M. C. and Weller, A., S.
J. Am. Chem. Soc., 2018, 140, 7347

35. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
Jennings, L. E., Schiedel, M., Hewings, D. S., Picaud, S., Laurin, C. M. C., Bruno, P. A., Bluck, J. P., Scorah, A. R., See, L., Reynolds, J. K., Moroglu, M., Mistry, I. N., Hicks, A., Guzanov, P., Clayton, J., Evans, C., Stazi, G., Biggin, P. C., Mapp. A. K., Hammond, E. M., Humphreys, P. G., Filippakoulous, P., Conway, S. J.
Bioorg. Med. Chem., 2018, 26, 2937.

34. Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
Ascough, D. M. H., Pupo, G., Ibba, F., Vicini, A. C., Ricci, P., Christensen, K. E., Pfeifer, L. Morphy, J. R., Brown, J. M., Paton, R. S. and Gouverneur, V.
Science, 2018, 360, 638.

33. An enamine controlling group for rhodium-catalyzed intermolecular hydroacylation
Straker, R. N., Formica, M., Lupton, J. D., Niu, J. and Willis, M. C.
Tetrahedron, 2018, 74, 5408.

32. Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2
Moustakim, M., Riedel, K., Schuller, M., Gehring, A. P., Monteiro, O. P., Martin, S. P., Fedorov, O., Heer, J., Dixon, D. J., Elkins, J. M., Knapp, S., Bracher, F. and Brennan, P. E.
Bioorg. Med. Chem., 2018, 26, 2965.

31. Molecular machines for catalysis
van Dijk, L., Tilby, M. J., Szpera, R., Smith, O. A., Bunce, H. A. P. and Fletcher, S. P.
Nature Rev. Chem., 2018, 2, 0117.

30. Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases
Zhang, D., Markoulides, M. S., Stepanovs, D., Rydzik, A. M., El-Hussein, A., Bon, C., Kamps, J. J. A. G., Umland, K.-D., Collins, P. M., Cahill, S. T., Wanga, D. Y., von Delft, F., Brem, J., McDonough, M. A. and Schofield, C. J.
Bioorg. Med. Chem., 2018, 26, 2928.

29. Spironaphthoxazine switchable dyes for biological imaging
Xiong, Y., Vargas Jentzsch, A., Osterrieth, J. W. M., Sezgin, E., Sazanovich, I. W., Reglinski, K., Galiani, S., Parker, A. W., Eggeling, C. and Anderson, H. L.
Chem. Sci., 2018, 9, 3029.

28. Formation of quaternary centres by copper catalysed asymmetric conjugate addition to β-substituted cyclopentenones with the aid of a quantitative structure–selectivity relationship
Ardkhean, R., Mortimore, M., Paton, R. S. and Fletcher, S. P.
Chem. Sci., 2018, 9, 2628.

27. Synthesis of Polyynes Using Dicobalt Masking Groups
Kohn, D. R., Gawel, P., Xiong, Y., Christensen, K. E. and Anderson, H. L.
J. Org. Chem., 2018, 83, 2077.

26. Detecting Mechanochemical Atropisomerization within an STM Break Junction
Leary, E., Roche, C., Jiang, H., Grace, I., González, M. T., Rubio-Bollinger, G., Romero-Muñiz, C., Xiong, Y., Al-Galiby, Q., Noori, M., Lebedeva, M. A., Porfyrakis, K., Agrait, N., Hodgson, A., Higgins, S. J., Lambert, C. J., Anderson, H. L. and Nichols, R. J
J. Am. Chem. Soc., 2018, 140, 710.

25. Total synthesis of (−)-himalensine A
Shi, H., Michaelides, I. N., Darses, B., Jakubec, P., Nguyen, Q. N. N., Paton, R. S. and Dixon, D. J.
J. Am. Chem. Soc. 2017, 139, 17755.

24. Hexafluoroisopropanol as a highly versatile solvent
Colomer, I., Chamberlain, A. E. R., Haughey, M. B., Donohoe, T. J.
Nature Rev. Chem. 2017, 1, 0088.

23. One-pot, Three-Component Sulfonimidamide Synthesis exploiting the Sulfinylamine Reagent N-Sulfinyltritylamine, TrNSO
Davies, T. Q., Hall, A. and Willis, M. C.
Angew. Chem. Int. Ed. 2017, 56, 14937.

22. Copper-Catalyzed Synthesis and Applications of Yndiamide
Mansfield, S. J., Christensen, K. E., Thompson, A. L., Ma, K., Jones, M. W., Mekareeya, A. and Anderson​, E. A.
Angew. Chem. Int. Ed. 2017, 56, 14428.

21. Enantioselective Conjugate Addition Catalyzed by a Copper Phosphoramidite Complex: Computational and Experimental Exploration of Asymmetric Induction
Ardkhean, R.,  Roth, P. M. C., Maksymowicz, R. M., Curran, A., Peng, Q., Paton, R. S. and Fletcher, S. P.
ACS Catal. 2017, 7, 6729.

20. Crotonases - Nature's Exceedingly Convertible Catalysts
Lohans, C. T., Wang, D. Y., Wang, J., Hamed, R. B., Schofield, C. J.
ACS Catal. 2017, 7, 6587.

19. Exploiting Carbonyl Groups to Control Intermolecular Rhodium-Catalyzed Alkene and Alkyne Hydroacylation
Coxon, T. J., Fernandez, M., Barwick-Silk, J., McKay, A. I., Britton, L. E., Weller, A. S., Willis, M. C.
J. Am. Chem. Soc. 2017, 139, 10142.

18. Visible light photocatalysis of 6π heterocyclization
Münster, N., Parker, N. A., van Dijk, L., Paton, R. S., Smith, M. D.
Angew. Chem. Int. Ed. 2017, 56, 9468.

17. Unexpected Interactions between Alkyl Straps and Pyridine Ligands in Sulfur-Strapped Porphyrin Nanorings
Roche, C., Lou, Q., Gil-Ramirez, G., Jiang, H.-W., Kohn, D. R., Xiong, Y., Thompson, A. L., Anderson, H. L.
J. Org. Chem. 2017, 82, 7446.

16. Potential for minimal self-replicating systems in a dynamic combinatorial library of equilibrating imines
Morrow, S. M., Bissette, A. J., Fletcher, S. P.
Tetrahedron 2017, 73, 5005.

15. Transmission of chirality through space and across length scales
Morrow, S. M., Bissette, A. J. and Fletcher, S. P.
Nature Nanotechnology 2017, 12, 410.

14. Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate
Zhang, Z., Smart, T. J., Choi, H., Hardy, F., Lohansa, C. T., Abboud, M. I., Richardson, M. S. W., Paton, R. S., McDonough, M. A. and Schofield, C. J.
Proc. Natl. Acad. Sci. 2017, 114, 4667. 

13. Neutral iodotriazole foldamers as tetradentate halogen bonding anion receptors
Borissov, A., Lim, J. Y. C., Brown, A., Christensen, K. E., Thompson, A. L., Smith, M. D. and Beer, P. D.
Chem. Commun. 2017, 53, 2483.

12. Discovery of a PCAF Bromodomain Chemical Probe
Moustakim, M., Clark, P. G. K., Trulli, L., Fuentes de Arriba, A. L., Ehebauer, M. T., Chaikuad, A., Murphy, E. J., Mendez-Johnson, J., Daniels, D., Hou, C.-F. D., Lin, Y.-H., Walker, J. R., Hui, R., Yang, H., Dorrel, L., Rogers, C. M., Monteiro, O. P., Fedorov, O., Huber, K. V. M., Knapp, S., Heer, J., Dixon, D. J., Brennan, P. E.
Angew. Chem. Int. Ed. 2017, 56, 827. DOI: 10.1002/anie.201610816.

11. Umpolung synthesis of branched α-functionalized amines from imines via photocatalytic three-component reductive coupling reactions
Fuentes de Arriba, A. L., Urbitsch, F., Dixon, D. J.
Chem. Commun. 2016, 52, 14434.

10. A Cascade Strategy Enables a Total Synthesis of (+/-)-Morphine
Chu, S., Münster, N., Balan, T., Smith. M. D.
Angew. Chem. Int. Ed. 2016, 55, 14306.

9. Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity
Wright, T. H., Bower, B. J., Chalker, J. M., Bernardes, G. J. L., Wiewiora, R., Ng, W.-L., Raj, R., Faulkner, S., Vallée, M. R. J., Phanumartwiwath, A., Coleman, O. D., Thézénas, M.-L., Khan, M., Galan, S. R. G., Lercher, L., Schombs, M. W., Gerstberger, S., Palm-Espling, M. E., Baldwin, A. J., Kessler, B. M., Claridge, T. D. W., Mohammed, S. and Davis, B. G.
Science 2016, 354, 597.

8. Chemical Probes and Inhibitors of Bromodomains outside the BET family
Moustakim, M., Clark, P. G. K., Hay, D. A., Dixon, D. J. and Brennan, P. E.
Med. Chem. Commun. 2016, 7, 2246.

7. Photoswitchable Spiropyran Dyads for Biological Imaging
Xiong, Y., Rivera-Fuentes, P., Sezgin, E., Jentzsch, A. V., Eggeling, C. and Anderson, H. L.
Org. Lett. 2016, 8, 3666.

6. Cp₂ZrMeCl: A Reagent for Asymmetric Methyl Addition
Garrec, K. and Fletcher, S. P.
Org. Lett. 2016, 8, 3814.

5. Recent Applications in Natural Product Synthesis of Dihydrofuran and -pyran Formation by Ring-closing Alkene Metathesis
Jacques, R., Pal, R., Parker, N. A., Sear, C. E., Smith, P. W., Ribaucourt, A. and Hodgson, D. M.
Org. Biomol. Chem. 2016, 14, 5875.

4. Organocatalytic Enantioselective Desymmetrisation
Borissov, A., Davies, T. Q., Ellis, S. R., Fleming T. F., Richardson, M. S. W. and Dixon, D. J.
Chem. Soc. Rev. 2016, 45, 5474.

3. Cascade Polycyclizations in Natural Product Synthesis
Ardkhean, R., Caputo, D. F. J., Morrow, S. M., Shi H., Xiong, Y and Anderson, E. A.
Chem. Soc. Rev. 2016, 45, 1557.

2. Strategic Application and Transformation of ortho-Disubstituted Phenyl and Cyclopropyl Ketones to Expand the Scope of Hydrogen Borrowing Catalysis
Frost, J. R., Cheong, C. B., Akhtar, W. M., Caputo, D. F. J., Stevenson, N. G. and Donohoe, T. J.
J. Am. Chem. Soc. 2015, 137, 15664.

1. Active-Metal Template Synthesis of a Halogen-Bonding Rotaxane for Anion Recognition
Langton, M. J., Xiong, Y. and Beer, P. D.
Chem. Eur. J. 2015, 21, 18910.