P8. Stereoselective Alder-ene Reactions of Bicyclo[1.1.0]butanes: Facile Synthesis of Cyclopropyl- and Aryl-substituted Cyclobutenes.
Dasgupta, A., Bhattacharjee, S., Tong, Z., Guin, A., McNamee, R., Christensen, K., Biju, A. and Anderson, E. A.
ChemRxiv, 2023, Preprint.

P7. Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein.
Chan, H. H. T, Brewitz, L., Strain-Damerell, C., Lukacik, P., Walsh, M. A., Schofield, C. J. and Duarte, F.
bioRxiv, 2023, Preprint.

P6. A radical-polar crossover approach to complex nitrogen heterocycles via the triplet state.
Lockhart, Z., Popescu, M., Alegre-Requena, J., Ahuja, J, Paton, R. and Smith, M. D.
ChemRxiv, 2023, Preprint.

P5. 1,2-Redox Transpositions of Tertiary Amides.
Shennan, B., Sanchez Alonso, S. and Dixon, D. J.
ChemRxiv, 2023, Preprint.

P4. How do donor and acceptor substituents change the photophysical and photochemical behavior of dithienylethenes? The search for a water-soluble visible-light photoswitch.
Qiu, S., Frawley, A., Leslie, K. and Anderson, H. L.
ChemRxiv, 2023, Preprint.

P3. Harnessing triaryloxonium ions for aryne generation.
Smith, O., Hindson, M., Sreenithya, A., Tataru, V., Paton, R., Burton, J. and Smith, M. D.
ChemRxiv, 2023, Preprint.

P2. Taming non-classical carbocations to control small ring reactivity.
McNamee, R. E., Frank, N., Christensen, K, Duarte, F. and Anderson, E. A.
ChemRxiv, 2023, Preprint.

P1. Intact nucleosomal context enables chromodomain reader MRG15 to distinguish H3K36me3 from -me2.
Faulkner, S., Couturier, A. M., Josephson, B., Watts, T., Davis, B. G. and Esashi, F.
bioRxiv, 2020, Preprint.

265. Fluorochemicals from fluorspar via a phosphate-enabled mechanochemical process that bypasses HF.
Patel, C., André-Joyaux, E., Leitch, J. A., Martínez De Irujo-Labalde, X., Ibba, F., Struijs, J., EllWanger, M. A., Paton, R., Browne, D. L., Pupo, G., Aldridge, S., Hayward, M. A. and Gouverneur, V.
Science, 2023, 381, 302.

264. Synthesis of Cyclopropanes via Hydrogen-Borrowing Catalysis.
Crompton, J. L., Frost, J. R., Rowe, S. M., Christensen, K. E. and Donohoe, T. J.
Org. Lett., 2023, 25, 5253.

263. Engineering cellular communication between light-activated synthetic cells and bacteria.
Smith, J. M., Hartmann, D. and Booth, M. J.
bioRxiv, 2022, Preprint.
Nat. Chem. Biol., 2023, Accepted Article.

262. Redox Reorganization: Aluminium Promoted 1,5-Hydride Shifts Allow the Controlled Synthesis of Multisubstituted Cyclohexenes.
Smith, L., Armstrong, R., Hou, J., Smith, E., Sze, M., Sterling, A., Smith, A., Duarte, F. and Donohoe, T. J.
Angew. Chem. Int. Ed., 2023, Early View.

261. Solution-processable polymers of intrinsic microporosity for gas-phase carbon dioxide photoreduction.
Moruzzi, F., Zhang, W., Purushothaman, B., Gonzalez-Carrero, S., Aitchison, C., Willner, B., Ceugniet, F., Lin, Y., Kosco, J., Chen, H., Tian, J., Alsufyani, M, Gibson, J., Rattner, E., Baghdadi, Y., Eslava, S., Neophytou, M., Durrant, J., Steier, L. & McCulloch, I.
Nat. Commun., 2023, 14, 3443.

260. Dynamical nonequilibrium molecular dynamics simulations identify allosteric sites and positions associated with drug resistance in the SARS-CoV-2 main protease.
Chan, H.T.H., Oliveira, A.S.F., Schofield, C.J., Mulholland, A.J. and Duarte, F.
bioRxiv, 2022, Preprint.
JACS Au, 2023, 3, 1767.

259. A general scheme for generating NMR supersequences combining high- and low-sensitivity experiments.
Yong, J.R.J., Kupčeb E. and Claridge, T.D.W.
Chem. Commun., 2023, 59, 7827.

258. Templated 2D Polymer Heterojunctions for Improved Photocatalytic Hydrogen Production.
Aitchison, C.M., Gonzalez- Carrero, S., Yao, S., Benkert, M., Ding, Z., Young, N.P., Willner, B., Moruzzi, F., Lin, Y., Tian, J., Nellist, P.D., Durrant, J.R. and McCulloch, I.
Adv. Mater., 2023, Early View.

257. Catalytic Enantioselective Intramolecular Oxa-Michael Reaction to α,β-Unsaturated Esters and Amides.
Su, G., Formica, M., Yamazaki, K., Hamlin, T. A. and Dixon, D. J.
J. Am. Chem. Soc., 2023, 145, 12771.

256. Catalytic Enantioselective Nucleophilic Desymmetrisation of Phosphonate Esters.
Formica, M., Rogova, T., Shi, H., Sahara, N., Ferko, B., Farley, A., Christensen, K., Duarte, F., Yamazaki, K. and Dixon, D. J.
ChemRxiv, 2021, Preprint.
Nature Chem., 2023, 15, 714.

255. Orthogonal Light-Activated DNA for Patterned Biocomputing within Synthetic Cells.
Hartmann, D., Chowdhry, R., Smith, J. and Booth, M.
ChemRxiv, 2022, Preprint.
J. Am. Chem. Soc., 2023, 145, 9471.

254. Precise, Orthogonal Remote-Control of Cell-Free Systems Using Photocaged Nucleic Acids.
Mazzotti, G., Hartmann, D. and Booth, M.
ChemRxiv, 2023, Preprint.
J. Am. Chem. Soc., 2023, 145, 9481.

253. Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function.
Coleman, O. D., Macdonald, J., Thomson, B., Ward, J. A., Stubbs, C. J., McAllister, T. E., Clark, S., Amin, S., Cao, Y., Abboud, M. I., Zhang, Y, Sanganee, H., Huber, K. V. M. Claridge, T. D. W. and Kawamura, A.
Chem. Sci., 2023, 14, 7136.

252. Handcuffed antisense oligonucleotides for light-controlled cell-free expression.
Hartmann, D. and Booth, M.
Chem. Commun., 2023, 59, 5685.

251. Accessible light-controlled knockdown of cell-free protein synthesis using phosphorothioate-caged antisense oligonucleotides.
Hartmann, D. and Booth, M.
ChemRxiv, 2022, Preprint.
Commun. Chem., 2023, 6, 59.

250. A photoswitchable solvatochromic dye for probing membrane ordering by RESOLFT super-resolution microscopy.
Frawley, A., Leslie, K., Wycisk, V., Galiani, S., Shrestha, D., Eggeling, C. and Anderson, H. L.
ChemRxiv, 2023, Preprint.
ChemPhysChem, 2023, 24, e202300125.

249. Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5.
Tumber, A., Salah, E., Brewitz, L., Corner, T. P. and Schofield, C. J.
RSC Chem. Biol., 2023, 4, 399.

248. Mobile Molecules: Reactivity Profiling Guides Faster Movement on a Cysteine Track.
Bo, Z., Lim, Z. H., Duarte, F., Bayley, H., Qing, Y.
Angew. Chem. Int. Ed., 2023, 62, e202300890.

247. Bifunctional Iminophosphorane-Catalyzed Enantioselective Nitroalkane Addition to Unactivated α,β-Unsaturated Esters.
Rozsar, D., Farley, A., McLauchlan, I., Shennan, B. A., Yamazaki, K. and Dixon, D. J.
ChemRxiv, 2022, Preprint.
Angew. Chem. Int. Ed., 2023, 62, e202303391.

246. Control of stereogenic oxygen in a helically chiral oxonium ion.
Smith, O., Popescu, M., Hindson, M., Paton, R., Burton, J. and Smith, M. D.
ChemRxiv, 2022, Preprint.
Nature, 2023, 615, 430.

245. Visible Light Photoredox-Catalyzed Decarboxylative Alkylation of 3-Aryl-Oxetanes and Azetidines via Benzylic Tertiary Radicals and Implications of Benzylic Radical Stability.
Dubois, M. A. J., Rojas, J. J., Sterling, A. J., Broderick, H. C., Smith, M. A., White, A. J. P., Miller, P. W., Choi, C., Mousseau, J. J., Duarte, F. and Bull, J. A.
J. Org. Chem., 2023, 88, 6476.

244. Stereoretentive Post-Translational Protein Editing.
Fu, X-P., Yuan, Y., Jha, A., Levin, N., Giltrap, A. M., Ren, J., Mamalis, D., Mohammed, S. and Davis, B. G.
ACS Cent. Sci., 2023, 9, 405.

243. Enantioselective Total Synthesis of (−)-Himalensine A via a Palladium and 4-Hydroxyproline Co-catalyzed Desymmetrization of Vinyl-bromide-tethered Cyclohexanones.
Kučera, R., Ellis, S. E., Yamazaki, K., Hayward Cooke, J., Chekshin, N., Christensen, K. E., Hamlin, T. A. and Dixon, D. J.
J. Am. Chem. Soc., 2023, 145, 5422.

242. Catalytic enantioselective 6𝝿 photocyclization of acrylanilides
Jones, B., Solon, P., Popescu, M., Du, J.-Y., Paton, R. and Smith, M. D.
ChemRxiv, 2022, Preprint.
J. Am. Chem. Soc., 2023, 145, 171.

241. Enantioselective synthesis of atropisomeric indoles via iron-catalysed oxidative cross-coupling
Surgenor, R., Liu, X., Keenlyside, M., Myers, W. and Smith M. D.
ChemRxiv, 2021, Preprint.
Nat. Chem., 2023, 15, 357.

240. Alcohols as efficient intermolecular initiators for a highly stereoselective polyene cyclisation cascade.
Aynetdinova, D., Jacques, R., Christensen, K. and Donohoe, T. J.
Chem. Eur. J., 2023, 29, e202203732.

239. Total Synthesis and Structure Confirmation of (E) and (Z)-Ocellenyne.
Hicks, H. B., Brown, D. S., Chan, H. S. S., Sousa, B. A., Christensen, K. E. and Burton, J. W.
Org. Lett., 2022, 24, 9174.

238. Photo-switchable anion binding and catalysis with a visible light responsive halogen bonding receptor.
Kerckhoffs, A., Moss, I. and Langton, M. J.
Chem. Commun., 2023, 59, 51.

237. Recent advances in the dearomative functionalisation of heteroarenes.
Kratena, N., Marinic, B. and Donohoe, T. J.
Chem. Sci., 2022, 13, 14213.

236. Rapid and scalable halosulfonylation of strain-release reagents.
Pickford, H. D., Ripenko, V., McNamee, R. E., Holovchuk, S., Thompson, A. L., Smith, R. C., Mykhailiuk, P. K. and Anderson, E. A.
ChemRxiv, 2022, Preprint.
Angew. Chem. Int. Ed., 2023, 62, e202213508.

235. Rhodium-Catalyzed [2 + 2 + 2] Cyclotrimerizations of Yndiamides with Alkynes.
Smith, P. J., Tong, Z., Ragus, J., Solon, P., Shimkin, K. W. and Anderson, E. A.
Org. Lett., 2022, 24, 7522.

234. Enantioselective oxidation of unactivated C–H bonds in cyclic amines by iterative docking-guided mutagenesis of P450_BM3 (CYP102A1).
Zhang, Y., Xiong, Z., Li, Y., Wilson, M., Christensen, K. E., Jaques, E., Hernández-Lladó, P., Robertson, J. and Wong, L. L.
Nat. Synth., 2022, 1, 936.

233. Fast relaxing red and near-IR switchable azobenzenes with chalcogen and halogen substituents: periodic trends, tuneable thermal half-lives and chalcogen bonding.
Kerckhoffs, A., Christensen, K. E. and Langton, M. J.
Chem. Sci., 2022, 13, 11551.

232. Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane.
Frank, N., Nugent, J., Shire, B.R., Pickford, H. D., Rabe, P., Sterling, A. J., Zarganes-Tzitzikas, T., Grimes, T., Thompson, A. L., Smith, R. C., Schofield, C. J., Brennan, P. E., Duarte, D. and Anderson, E. A.
ChemRxiv, 2022, Preprint.
Nature, 2022, 611, 721.

231. Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains.
Sekirnik, A., Reynolds, J., See, L., Bluck, J., Scorah, A., Tallant, C., Lee, B., Leszczynska, K., Grimley, R., Storer, R. I., Malattia, M, Crespillo, S., Caria, S., Duclos, S., Hammond, E. M., Knapp, S., Morris, G. M., Duarte, F., Biggin, P., and Conway, S. J.
ChemRxiv, 2022, Preprint.
ACS Chem. Biol., 2022, 17, 2753.

230. A One-Pot Synthesis-Functionalization Strategy for Streamlined Access to 2,5-Disubstituted 1,3,4-Oxadiazoles from Carboxylic Acids.
Matheau-Raven, D. and Dixon, D. J.
J. Org. Chem., 2022, 87, 12498.

229. Towards fully optimised and automated ESR spectroscopy.
Verstraete, J.-B., Yong, J. R. J., Goodwin, D. L., Myers, W. K. and Foroozandeh, M.
Chem. Commun., 2022, 58, 10715.

228. A Vicinal Diol Approach for the Total Synthesis of Molestin E, ent-Sinulacembranolide A and ent-Sinumaximol A.
Hoff, O., Kratena, N., Aynetdinova, D., Christensen, K. E. and Donohoe, T. J.
Chem. Eur. J., 2022, 28, e202202464.

227. Counterion-Mediated Enantioconvergent Synthesis of Axially Chiral Medium Rings.
Du, J.-Y., Balan, T., Claridge, T. D. W. C and Smith, M. D.
J. Am. Chem. Soc., 2022, 144, 14790.

226. N-Sulfinyl-O-(tert-Butyl)Hydroxylamine.
Davies, T. Q. and Willis, M. C.
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225. An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.
Baker, Y.R., Thorpe, C., Chen, J., Poller, L. M., Cox, L., Kumar, P., Lim, W. F., Lie, L., McClorey, G., Epple, S., Singleton, D., McDonough, M. A., Hardwick, J. S., Christensen, K. E., Wood, M. J. A., Hall, J. P., El-Sagheer, A. H., and Brown, T.
Nat. Commun., 2022, 13, 4036.

224. Alcohols as Alkylating Agents in the Cation-Induced Formation of Nitrogen Heterocycles.
Cox, L., Zhu, Y., Smith, P. J., Christensen, K. E., Sidera Portela, M. and Donohoe, T. J.
Angew. Chem. Int. Ed., 2022, 61, e202206800.

223. Branching out: redox strategies towards the synthesis of acyclic α-tertiary ethers.
Shennan, B. D. A., Berheci, D., Crompton, J. L., Davidson, T. A., Field, J. L., Williams, B. A and Dixon, D. J.
Chem. Soc. Rev., 2022, 51, 5878.

222. Modular Two-Step Route to Sulfondiimidamides.
Zhang, Z.-X., Bell, C., Ding, M. and Willis, M. C.
J. Am. Chem. Soc., 2022, 144, 11851.

221. An autonomously oscillating supramolecular self-replicator.
Howlett, M.G., Engwerda, A.H.J., Scanes, R.J.H. and Fletcher, S. P.
Nat. Chem., 2022, 14, 805.

220. Evolution of the Dearomative Functionalization of Activated Quinolines and Isoquinolines: Expansion of the Electrophile Scope.
Kischkewitz, M., Marinic, B., Kratena, N., Lai, Y., Hepburn, H. B., Dow, M., Christensen, K. E. and Donohoe,T. J.
Angew. Chem. Int. Ed., 2022, 61, e202204682.

219. Photocatalytic Late- Stage Functionalization of Sulfonamides via Sulfonyl Radical Intermediates.
Tilby, M.J ., Dewez, D. F., Pantaine, L. R. E., Hall, A., Martínez-Lamenca, C. and Willis, M. C.
ACS Catal., 2022, 12, 6060.

218. Extension of hydrogen borrowing alkylation reactions for the total synthesis of (−)-γ-lycorane.
Hall, C., Marriott, I., Christensen, K., Day, A., Goundry, W. and Donohoe, T. J.
Chem. Commun., 2022, 58, 4966.

217. [¹⁸F]Difluorocarbene for Positron Emission Tomography.
Sap, J.B.I., Meyer, C.F., Ford, J., Straathof, N., Dürr, A., Lelos, M., Paisey, S., Mollner, T., Hell, S., Trabanco, A., Genicot, C., am Ende, C., Paton, R. S., Tredwell, M. and Gouverneur, V..
Nature, 2022, 606, 102.

216. Transition Metal-Free, Visible Light-Mediated Radical Cyclisation of Malonyl Radicals onto 5-Ring Heteroaromatics.
Hernández-Lladó, P., Garrec, K., Schmitt, D. and Burton, J.
Adv. Synth. Catal., 2022, 364, 1724.

215. Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins.
Kamps, J.J.A.G., Belle, R., Poater, J., Kumar, K., Pieters, B., Salah, E., Claridge, T. D. W., Paton, R., S., Bickelhaupt, F. M., Kawamura, A., Schofield, C. J. and Mecinović, J.
Commun. Chem., 2022, 5, 27.

214. Asymmetric Azidation under Hydrogen Bonding Phase-Transfer Catalysis: A Combined Experimental and Computational Study.
Wang, J., Horwitz, M. A., Dürr, A. B., Ibba, F., Pupo, G., Gao, Y., Ricci, P., Christensen, K. E., Pathak, T. P., Claridge, T. D. W. C., Lloyd-Jones, G. C., Paton, R. S. and Gouverneur, V.
J. Am. Chem. Soc., 2022, 144, 4572.

213. A Silyl Sulfinylamine Reagent Enables the Modular Synthesis of Sulfonimidamides via Primary Sulfinamides.
Ding, M., Zhang, Z.-X., Davies, T. Q. and Willis, M. C.
Org. Lett., 2022, 24, 1711.

212. Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides.
Rojas, J. J., Croft, R. A., Sterling, A. J., Briggs, E. L., Antermite, D., Schmitt, D., Blagojevic, L., Haycock, P., White, A., Duarte, F., Choi, C., Mousseau, J. and Bull, J. A.
Nat. Chem., 2022, 14, 160.

211. DABSO – A Reagent to Revolutionize Organosulfur Chemistry.
Andrews, J. A. and Willis, M. C.
Synthesis, 2022, 54, 1695.

210. Modular Pulse Program Generation for NMR Supersequences.
Yong, J. R. J., Kupce, E. and Claridge, T. D. W.
Anal. Chem., 2022, 94, 2271.

209. Diverse saturated heterocycles from a hydroacylation/conjugate addition cascade.
Iwumene, N. U. N., Moseley, D. F., Pullin, R. C. and Willis, M. C.
Chem. Sci., 2022, 13, 1504.

208. Characterisation of the SARS-CoV-2 ExoN (nsp14^ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification.
Baddock, H., Brolih, S., Yosaatmadja, Y., Ratnaweera, M., Bielinski, M., Swift, L., Cruz-Migoni, A., Fan, H., Keown, J., Walker, A., Morris, G. M., Grimes, J., Fodor, E., Schofield, C. J., Gileadi, O. and McHugh, P. J.
bioRxiv, 2020, Preprint.
Nucleic Acids Res., 2022, 50, 1484.

207. A New Organocatalytic Desymmetrization Reaction Enables the Enantioselective Total Synthesis of Madangamine E.
Shiomi, S., Shennan, B., Yamazaki, K., Fuentes de Arriba, Á.L., Vasu, D., Hamlin, T. A. and Dixon, D. J.
ChemRxiv, 2021, Preprint.
J. Am. Chem. Soc., 2022, 144, 1407.

206. Bifunctional Iminophosphorane-Catalyzed Enantioselective Sulfa-Michael Addition to Unactivated α,β-Unsaturated Amides.
Rozsar, D., Formica, M., Yamazaki, K., Hamlin, T. and Dixon, D. J.
ChemRxiv, 2021, Preprint.
J. Am. Chem. Soc., 2022, 144, 1006.

205. Synthesis and Applications of Polysubstituted Bicyclo[1.1.0]butanes.
McNamee, R. E., Thompson, A. L. and Anderson E. A.
J. Am. Chem. Soc., 2021, 143, 21246.

204. Synthesis and Application of Constrained Amidoboronic Acids Using Amphoteric Boron-Containing Building Blocks.
Soor, H. S., Diaz, D. B., Tsui, K. Y., Calvopiña, K., Bielinski, M., Tantillo, D. J., Schofield, C. J. and Yudin, A. K.
J. Org. Chem., 2022, 87, 94.

203. Single photon double and triple ionization of allene.
Ideböhn, V., Sterling, A. J., Wallner, M., Olsson, E., Squibb, R. J., Miniotaite, U., Forsmalm, E., Forsmalm, M., Stranges, S., Dyke, J. M., Duarte, F., Eland, J. H. D., and Feifel, R.
Phys. Chem. Chem. Phys., 2022, 24, 786.

202. First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
Nowak, R., Tumber, A., Hendrix, E., Ansari, M., Sabatino, M., Antonini, L., Andrijes, R., Salah, E., Mautone, N., Pellegrini, F., Simelis, K., Kawamura, A., Johansson, C., Passeri, D., Pellicciari, R., Ciogli, A., Del Bufalo, D., Ragno, R., Coleman, M., Trisciuoglio, D., Mai, A., Oppermann, U., Schofield, C. J. and Rotili, D.
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201. Lactone Backbone Density in Rigid Electron-Deficient Semiconducting Polymers Enabling High n-type Organic Thermoelectric Performance.
Alsufyani, M., Stoeckel, M.-A., Chen, X., Thorley, K., Hallani, R.K., Puttisong, Y., Ji, X., Meli, D., Paulsen, B.D., Strzalka, J., Regeta, K., Combe, C., Chen, H., Tian, J., Rivnay, J., Fabiano, S. and McCulloch, I.
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200. Parallel NMR Supersequences: Ten Spectra in a Single Measurement.
Kupče, E., Yong, J. R. J., Widmalm, G. and Claridge, T. D. W.
JACS Au, 2021, 1, 1892.

199. Electrophilic Activation of [1.1.1]Propellane for the Synthesis of Nitrogen-Substituted Bicyclo[1.1.1]pentanes.
Livesley, S., Sterling, A.J., Robertson, C.M., Goundry, W.R.F., Morris, J.A., Duarte, F. and Aïssa, C.
Angew. Chem. Int. Ed., 2022, 61, e202111291.

198. Benzenemethanamine, α,α-Diphenyl-N-Sulfinyl-.
Tilby, M. and Willis, M. C.
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197. Synthesis of α-Quaternary Bicyclo[1.1.1]pentanes through Synergistic Organophotoredox and Hydrogen Atom Transfer Catalysis.
Nugent, J., Sterling, A. J., Frank, N., Mousseau, J. J. and Anderson, E. A.
Org. Lett., 2021, 23, 8628.

196. Sulfinates from Amines: A Radical Approach to Alkyl Sulfonyl Derivatives via Donor–Acceptor Activation of Pyridinium Salts.
Andrews, J., Pantaine, L., Palmer, C. F., Poole, D. L. and Willis, M. C.
Org. Lett., 2021, 23, 8488.

195. A Three-Component Ugi-Type Reaction of N-Carbamoyl Imines Enables a Broad Scope Primary α-Amino 1,3,4-Oxadiazole Synthesis.
Matheau-Raven, D., Boulter, E., Rogova, T. and Dixon, D. J.
Org. Lett., 2021, 23, 8209.

194. Red-shifted tetra-ortho-halo-azobenzenes for photo-regulated transmembrane anion transport.
Kerckhoffs, A., Bo, Z., Penty, S. E., Duarte, F. and Langton, M. J.
Org. Biomol. Chem., 2021, 19, 9058.

193. Exploiting Configurational Lability in Aza-Sulfur Compounds for the Organocatalytic Enantioselective Synthesis of Sulfonimidamides.
Tilby, M. J., Dewez, D. F., Hall, A., Martínez Lamenca, C. and Willis, M. C.
Angew. Chem. Int. Ed., 2021, 60, 25680.

192. A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility.
Epple, S., Modi, A., Baker, Y. R., Wȩgrzyn, E., Traoré, D., Wanat, P., Tyburn, A., Shivalingam, A., Taemaitree, L., El-Sagheer, A. and Brown, T.
J. Am. Chem. Soc., 2021, 143, 16293.

191. Azine-N-oxides as effective controlling groups for Rh-catalysed intermolecular alkyne hydroacylation.
Moseley, D. F., Kalepua, J. and Willis, M. C.
Chem. Sci., 2021, 12, 13068.

190. Discovery of SARS-CoV-2 Mpro Peptide Inhibitors from Modelling Substrate and Ligand Binding.
Chan, H. T. H., Moesser, M., Walters, R. K., Malla, T. R., Twidale, R. M., John, T., Deeks, H. M., Johnston-Wood, T., Mikhailov, V., Sessions, R. B., Dawson, W., Salah, E., Lukacik, P., Strain-Damerell, C., Owen, D., Nakajima, T., Swiderek, K., Lodola, A., Moliner, V., Glowacki, D. R., Walsh, M. A., Schofield, C. J., Genovese, L., Shoemark, D., Mulholland, A. J., Duarte, F. and Morris, G. M.
bioRxiv, 2021, Preprint.
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189. Regio- and stereoselective addition of Brønsted acids to yndiamides: Synthesis of N,O,N- and N,S,N-trisubstituted ketene acetals.
Garry, O. L., Mansfield, S. J. and Anderson, E. A.
Synthesis, 2021, 53, 4221.

188. Switchable, Reagent-Controlled Diastereodivergent Photocatalytic Carbocyclisation of Imine-Derived α-Amino Radicals.
Maitland, J. A. P., Leitch, J. A., Yamazaki, K., Christensen, K. E., Cassar, D. J., Hamlin, T. A. and Dixon, D. J.
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187. X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis.
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186. Selection between Competing Self-Reproducing Lipids: Succession and Dynamic Activation.
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185. A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
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182. Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions.
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181. On-the-Fly, Sample-Tailored Optimization of NMR Experiments.
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180. Supramolecular chemistry in lipid bilayer membranes.
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179. Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology.
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178. An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography.
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177. A General Iridium-Catalyzed Reductive Dienamine Synthesis Allows a Five-Step Synthesis of Catharanthine via the Elusive Dehydrosecodine.
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176. Controlling Intramolecular Interactions in the Design of Selective, High-Affinity, Ligands for the CREBBP Bromodomain.
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173. General α-Amino 1,3,4-Oxadiazole Synthesis via Late-Stage Reductive Functionalization of Tertiary Amides and Lactams.
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172. Twofold Radical-Based Synthesis of N,C-Difunctionalized Bicyclo[1.1.1]pentanes.
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168. Au(I)-Catalyzed Oxidative Functionalization of Yndiamides.
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167. Late-stage difluoromethylation: concepts, developments and perspective.
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166. Highly Active Halogen Bonding and Chalcogen Bonding Chloride Transporters with Non-Protonophoric Activity.
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164. Synthesis of 1,3-disubstituted bicyclo[1.1.0]butanes via directed bridgehead functionalization.
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163. Rediscovering Sulfinylamines as Reagents for Organic Synthesis.
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151. Synthesis of legonmycins A and B, C(7a)-hydroxylated bacterial pyrrolizidines.
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146. autodE: Automated Calculation of Reaction Energy Profiles – Application to Organic and Organometallic Reactions.
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138. The 2‐Pyridyl Problem: Challenging Nucleophiles in Cross‐Coupling Arylations.
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137. α-Tertiary Dialkyl Ether Synthesis via Reductive Photocatalytic α-Functionalization of Alkyl Enol Ethers.
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132. Super-resolution RESOLFT microscopy of lipid bilayers using a fluorophore-switch dyad.
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96. Bicyclic Lactams Derived from Serine or Cysteine and 2-Methylpropanal.
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95. Inhibitors of JmjC-Containing Histone Demethylases.
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94. ¹⁸F-Trifluoromethanesulfinate Enables Direct C–H ¹⁸F-Trifluoromethylation of Native Aromatic Residues in Peptides.
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93. Dearomative Photocatalytic Construction of Bridged 1,3-Diazepanes.
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92. Catalytic Asymmetric Suzuki–Miyaura Couplings.
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91. Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.
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90. Iridium-Catalyzed Reductive Coupling of Grignard Reagents and Tertiary Amides.
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89. Synthesis of highly fluorinated arene complexes of [Rh(chelating phosphine)]+ cations, and their use in synthesis and catalysis.
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88. ¹⁹F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode.
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87. How formaldehyde reacts with amino acids.
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86. Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase.
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85. Synthesis of Cyclic Alkenyl Dimethylsiloxanes from Alkynyl Benzyldimethylsilanes and Application in Polyene Synthesis
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84. Convergent Total Syntheses of (−)‐Rubriflordilactone B and (−)‐pseudo‐Rubriflordilactone B
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83. Highly enantioselective rhodium-catalyzed cross-coupling of boronic acids and racemic allyl halides.
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82. A General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis
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81. Desymmetrization of Meso-bisphosphates via Rhodium Catalyzed Asymmetric Allylic Arylation
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80. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
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79. Modular Sulfondiimine Synthesis Using a Stable Sulfinylamine Reagent
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78. Iridium-Catalyzed Aza-Spirocyclization of Indole-Tethered Amides: An Interrupted Pictet–Spengler Reaction
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77. Retooling Asymmetric Conjugate Additions for Sterically Demanding Substrates with an Iterative Data-Driven Approach
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76. Rhodium-catalysed vinyl 1,4-conjugate addition coupled with Sharpless asymmetric dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin-4
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75. Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications
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74. Intramolecular Aldol Ring Closures of Cysteine Derivatives Leading to Densely Functionalised Pyroglutamates
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73. Total Synthesis of Berkeleylactone A
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72. Dehydrodieugenol B derivatives as antiparasitic agents: Synthesis and biological activity against Trypanosoma cruzi
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71. A General Copper-Catalyzed Synthesis of Ynamides from 1,2-Dichloroenamides​
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70. A halogen-bonding foldamer molecular film for selective reagentless anion sensing in water
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69. Synthesis of Enantioenriched α‐Chiral Bicyclo[1.1.1]pentane​​
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68. A chemically fuelled self-replicator
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67. Practical and scalable kinetic resolution of BINOLs mediated by a chiral counterion
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66. Dithiane-Directed Rh(III)-Catalyzed Amidation of Unactivated C(sp3)-H Bonds
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65. The fluorination of C–H bonds: developments and perspectives​
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64. Primary α-Tertiary Amine Synthesis via α-C–H Functionalization
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63. Anion recognition in water by charge-neutral halogen and chalcogen bonding foldamer receptors​
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62. Chemical Probes​
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61. Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines
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60. Conformational Effects on Physical-Organic Descriptors – the Case of Sterimol Steric Parameters​
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59. Hydrogen bond enabled dynamic kinetic resolution of axially chiral amides mediated by a chiral counterion
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58. Chemical epigenetics: the impact of chemical‐ and chemical biology techniques on bromodomain target validation​
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57. Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
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56. Data-mining the diaryl(thio)urea conformational landscape: Understanding the contrasting behavior of ureas and thioureas with quantum chemistry
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55. Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by L,D‐Transpeptidases and Serine β‐Lactamase Cysteine Variants
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54. Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides
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53. Design, Synthesis and Characterization of Covalent KDM5 Inhibitors
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52. A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL)
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51. Target Identification Using Chemical Probes​
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50. Stereospecific 1,3-H Transfer of Indenols Proceeds via Persistent Ion-Pairs Anchored By NH···Pi Interactions
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49. Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes
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48. Discovery of an MLLT1/3 YEATS Domain Chemical Probe
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47. Enantioselective Silver-Catalyzed Cascade Synthesis of Fused Lactone and Lactam Oxazolines
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46. Post-translational site-selective protein backbone α-deuteration
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45. Principles and Applications of Fragment-based Drug Discovery for Chemical Probes
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44. Bifunctional Iminophosphorane Catalysed Enantioselective Sulfa-Michael Addition of Alkyl Thiols to Alkenyl Benzimidazoles
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43. Photocatalytic Reverse Polarity Povarov Reaction
Leitch, J. A., Fuentes de Arriba, A. L., Tan, J., Hoff, O., Martínez, C. M. and Dixon, D. J.
Chem. Sci., 2018, 9, 6653.

42. Polyyne formation via skeletal rearrangement induced by atomic manipulation
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41. A Bench-Stable Transfer Reagent for the Synthesis of Trifluoromethyl-sulfonimidamides from Sulfinamides
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40. A transient self-assembling self-replicator
Colomer, I., Morrow, S. M. and Fletcher S. P.
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39. The Plant Cysteine Oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors
White, Mark. D., Kamps, J. A. G., East, S., Taylor Kearney, L. J. and Flashman, E.
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38. Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis
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37. Synthesis and Applications of Highly Functionalized 1-Halo-3-Substituted Bicyclo[1.1.1]pentanes
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Chem. Sci., 2018, 9, 5295.

36. Rh(DPEPhos)-Catalyzed Alkyne Hydroacylation using β-Carbonyl Substituted Aldehydes. Mechanistic Insight Leads to Low Catalyst Loadings that Enables Selective Catalysis on Gram-Scale
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35. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
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34. Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
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33. An enamine controlling group for rhodium-catalyzed intermolecular hydroacylation
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32. Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2
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31. Molecular machines for catalysis
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30. Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases
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29. Spironaphthoxazine switchable dyes for biological imaging
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28. Formation of quaternary centres by copper catalysed asymmetric conjugate addition to β-substituted cyclopentenones with the aid of a quantitative structure–selectivity relationship
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27. Synthesis of Polyynes Using Dicobalt Masking Groups
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26. Detecting Mechanochemical Atropisomerization within an STM Break Junction
Leary, E., Roche, C., Jiang, H., Grace, I., González, M. T., Rubio-Bollinger, G., Romero-Muñiz, C., Xiong, Y., Al-Galiby, Q., Noori, M., Lebedeva, M. A., Porfyrakis, K., Agrait, N., Hodgson, A., Higgins, S. J., Lambert, C. J., Anderson, H. L. and Nichols, R. J
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25. Total synthesis of (−)-himalensine A
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24. Hexafluoroisopropanol as a highly versatile solvent
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23. One-pot, Three-Component Sulfonimidamide Synthesis exploiting the Sulfinylamine Reagent N-Sulfinyltritylamine, TrNSO
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22. Copper-Catalyzed Synthesis and Applications of Yndiamide
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21. Enantioselective Conjugate Addition Catalyzed by a Copper Phosphoramidite Complex: Computational and Experimental Exploration of Asymmetric Induction
Ardkhean, R.,  Roth, P. M. C., Maksymowicz, R. M., Curran, A., Peng, Q., Paton, R. S. and Fletcher, S. P.
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20. Crotonases - Nature's Exceedingly Convertible Catalysts
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19. Exploiting Carbonyl Groups to Control Intermolecular Rhodium-Catalyzed Alkene and Alkyne Hydroacylation
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18. Visible light photocatalysis of 6π heterocyclization
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17. Unexpected Interactions between Alkyl Straps and Pyridine Ligands in Sulfur-Strapped Porphyrin Nanorings
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16. Potential for minimal self-replicating systems in a dynamic combinatorial library of equilibrating imines
Morrow, S. M., Bissette, A. J., Fletcher, S. P.
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15. Transmission of chirality through space and across length scales
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14. Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate
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13. Neutral iodotriazole foldamers as tetradentate halogen bonding anion receptors
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12. Discovery of a PCAF Bromodomain Chemical Probe
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11. Umpolung synthesis of branched α-functionalized amines from imines via photocatalytic three-component reductive coupling reactions
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10. A Cascade Strategy Enables a Total Synthesis of (+/-)-Morphine
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9. Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity
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8. Chemical Probes and Inhibitors of Bromodomains outside the BET family
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7. Photoswitchable Spiropyran Dyads for Biological Imaging
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6. Cp₂ZrMeCl: A Reagent for Asymmetric Methyl Addition
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5. Recent Applications in Natural Product Synthesis of Dihydrofuran and -pyran Formation by Ring-closing Alkene Metathesis
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4. Organocatalytic Enantioselective Desymmetrisation
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3. Cascade Polycyclizations in Natural Product Synthesis
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2. Strategic Application and Transformation of ortho-Disubstituted Phenyl and Cyclopropyl Ketones to Expand the Scope of Hydrogen Borrowing Catalysis
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1. Active-Metal Template Synthesis of a Halogen-Bonding Rotaxane for Anion Recognition
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